Formal total synthesis of (±)-strictamine - the [2,3]-Stevens rearrangement for construction of octahydro-2H-2,8-methanoquinolizines

被引：38

作者：

Eckermann, Ruben ^{[1
]}

Breunig, Michael ^{[1
]}

Gaich, Tanja ^{[1
]}

机构：

[1] Univ Konstanz, Dept Chem, Univ Str 10, D-78457 Constance, Germany

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 76期

关键词：

PICRALIMA-NITIDA SEEDS; AKUAMMILINE ALKALOIDS; (+/-)-ASPIDOPHYLLINE; (+)-SCHOLARISINE; KLAINEANA;

D O I：

10.1039/c6cc06125g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For decades, akuammiline alkaloids have attracted synthetic chemists due to their intriguing molecular architecture. Among the different structural elements embedded in their carboskeleton, the methano-quinolizidine system constitutes the signature structural element of this alkaloid family. Herein, we describe a novel synthetic access to this system which relies on a [2,3]-Stevens rearrangement and results in the formal synthesis of strictamine.

引用

页码：11363 / 11365

页数：3

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