Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.

被引：131

作者：

Takashi, M

Mochida, K

Kozuka, M

Ito, Y

Fujiwara, Y

Hashimoto, K

Enjo, F

Ogata, M

Nobukuni, Y

Tokuda, H

Nishino, H

机构：

[1] Res Inst Prod Dev, Sakyo Ku, Kyoto 6060805, Japan

[2] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan

[3] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 2001年 / 172卷 / 02期

关键词：

Capsicum annuum; carotenoid; capsanthin; cancer chemopreventive activity; Epstein-Barr virus; early antigen two-stage mouse skin carcinogenesis;

D O I：

10.1016/S0304-3835(01)00635-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Capsanthin (1) and related carotenoids (2-7) isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester (3) and capsorbin diester (5) showed strong inhibitory effects. Furthermore, casanthin (1), capsanthin 3'-ester (2) and capsanthin 3,3'-diester (3), major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 109

页数：7

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