Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer

被引：23

作者：

Marabese, Mirko ^{[1
]}

Marchini, Sergio ^{[1
]}

Marrazzo, Eleonora ^{[1
]}

Mariani, Pietro ^{[1
]}

Cattaneo, Dario ^{[1
]}

Fossati, Roldano ^{[2
]}

Compagnoni, Anna ^{[2
]}

Signorelli, Mauro ^{[3
]}

Moll, Ute M. ^{[4
]}

Codegoni, A. Maria ^{[1
]}

Broggini, Massimo ^{[1
]}

机构：

[1] Ist Farmacol Mario Negri, Dept Oncol, Mol Pharmacol Lab, Milan, Italy

[2] Ist Ric Farmacol Mario Negri, Dept Oncol, Lab Translat Res & Clin Outcome, Milan, Italy

[3] Univ Milano Monza, Osped san Gerardo, Milan, Italy

[4] SUNY Stony Brook, Dept Pathol, Stony Brook, NY 11794 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2008年 / 44卷 / 01期

关键词：

p53; p73; ovarian cancer; splice variants;

D O I：

10.1016/j.ejca.2007.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The p53 gene has been investigated for its role in epithelial ovarian cancer but data collected until now are contradictory. The evidence that p53 belongs with p63 and p73 to a family of transcription factors re-opened interest in this gene family. Here, we used quantitative real time RT-PCR to determine expression levels of TAp53, TAp73 and their N-terminal splice variants in a cohort of 169 ovarian cancer patients with stage I and stage III disease. The TAp73 levels in stage III biopsies differed by 100-fold depending on the p53 status and overall survival appears to be significantly related to Delta Np73 expression. Kaplan-Meyer analyses did not suggest a correlation between overall survival and levels of TAp73, Delta Np73 or the Delta Np73/TAp73 ratio. In conclusion, these data suggest that at least in our patient cohort p53 and p73 expression levels are not correlated to malignant progression of ovarian cancer. They might, however, play a role in tumour initiation. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：131 / 141

页数：11

共 50 条

[21] Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer
Tannapfel, A
Schmelzer, S
Benicke, M
Klimpfinger, M
Kohlhaw, K
Mössner, J
Engeland, K
Wittekind, C
JOURNAL OF PATHOLOGY, 2001, 195 (02): : 163 - 170
[22] p73, a sophisticated p53 family member in the cancer world
Ozaki, T
Nakagawara, A
CANCER SCIENCE, 2005, 96 (11): : 729 - 737
[23] p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
F Murray-Zmijewski
D P Lane
J-C Bourdon
Cell Death & Differentiation, 2006, 13 : 962 - 972
[24] p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
Murray-Zmijewski, F.
Lane, D. P.
Bourdon, J-C
CELL DEATH AND DIFFERENTIATION, 2006, 13 (06): : 962 - 972
[25] p53 protein variants: structural and functional similarities with p63 and p73 isoforms
Courtois, S
de Fromentel, CC
Hainaut, P
ONCOGENE, 2004, 23 (03) : 631 - 638
[26] p73 competes with p53 and attenuates its response in a human ovarian cancer cell line
Vikhanskaya, F
D'Incalci, M
Broggini, M
NUCLEIC ACIDS RESEARCH, 2000, 28 (02) : 513 - 519
[27] p53 protein variants: structural and functional similarities with p63 and p73 isoforms
Stéphanie Courtois
Claude Caron de Fromentel
Pierre Hainaut
Oncogene, 2004, 23 : 631 - 638
[28] p63 and p73, the Ancestors of p53
Doetsch, V.
Bernassola, F.
Coutandin, D.
Candi, E.
Melino, G.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (09): : a004887
[29] From p53 to p63 and p73
不详
TRENDS IN GENETICS, 1999, 15 (06) : 222 - 222
[30] p53 and p73 Expression in Esophageal Carcinoma Correlate with Clinicopathology of Tumors
Ye, Bing
Wang, Xuefeng
Yang, Zhenzhong
Sun, Zhengping
Zhang, Rongbo
Hu, Youying
Lu, Youguo
Du, Jiuwei
HEPATO-GASTROENTEROLOGY, 2012, 59 (119) : 2192 - 2195

← 1 2 3 4 5 →