Effect of Ulipristal Acetate for Uterine Fibroids

BACKGROUND Fibroids are the most common tumours of the female reproductive tract and have been reported to affect 20-40% of women during their reproductive years. Most fibroids are asymptomatic and require no treatment. We wanted to investigate the effectiveness of Ulipristal Acetate in reducing the fibroid volume, and giving symptomatic relief after 3 months treatment. METHODS This is a prospective interventional study conducted among 38 premenopausal women with symptomatic fibroids. They were evaluated clinically for the symptoms reported. Each underwent ultrasound before starting the treatment and after three months of Ulipristal treatment. Some patients had more than one fibroid and so in total the sizes of 56 fibroids were recorded. RESULTS After 3 months of ulipristal acetate treatment, patients had a significant improvement of all symptoms with fibroid volume reduction. CONCLUSIONS Fibroid treatment with ulipristal acetate resulted in a significant improvement of fibroid related symptoms and significant reduction in fibroid volume.