Hypoglycemic and antioxidative effects of hydroxyethyl methylcellulose in mice fed with high fat diet

被引:4
|
作者
Ban, Su Jeong [1 ]
Rico, Catherine W. [1 ]
Um, In Chul [2 ]
Kang, Mi Young [1 ]
机构
[1] Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea
[2] Kyungpook Natl Univ, Dept Nat Fiber Sci, Taegu 702701, South Korea
基金
新加坡国家研究基金会;
关键词
Hydroxyethyl methylcellulose; Glucose metabolism; Antioxidative effect; Viscosity; High fat diet; OXIDATIVE STRESS; BLOOD-GLUCOSE; LIPID PEROXIDES; FIBER; HYDROXYPROPYLMETHYLCELLULOSE; CELLULOSE; OBESITY; ASSAY;
D O I
10.1016/j.fct.2012.02.032
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The effect of hydroxyethyl methylcellulose (HEMC) with different viscosities on the glucose metabolism and antioxidative defense system in high fat-fed mice was investigated. The mice were randomly divided into five dietary groups: normal control diet (NC), high fat diet (HF), and high fat diet supplemented with high viscosity (HF-HV), moderate viscosity (HF-MV), and low viscosity (HF-LV) HEMC fibers. After 6 weeks, the HF group showed a marked increase in body weight gain, body fat, blood glucose concentration, insulin level, and erythrocyte lipid peroxidation rate relative to the NC group. However, supplementation of HEMC in the diet suppressed these high fat-induced hyperglycemia and oxidative stress through enhancement of the activities of hepatic glucokinase and antioxidant enzymes. The hypoglycemic and antioxidative effects increased with increased viscosity of the HEMC consumed. These results illustrate that HEMC with high viscosity may be useful in the management of high fat diet-induced hyperglycemia and oxidative stress. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1716 / 1721
页数:6
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