[1,2,4]Triazino[2,3-N]quinazolines 2*. Synthesis, structure, and anticonvulsant activity of new 3'-R1-spiro[(aza/oxa/thia)cycloalkyl-1(3,4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones

被引：14

作者：

Voskoboynik, Oleksii Yu. ^{[1
]}

Kolomoets, Olexandra S. ^{[1
]}

Palchikov, Vitaliy A. ^{[2
]}

Kovalenko, Sergyi I. ^{[1
]}

Belenichev, Igor F. ^{[1
]}

Shishkina, Svetlana V. ^{[3
]}

机构：

[1] Zaporizhya State Med Univ, 26 Mayakovshogo Ave, UA-69035 Zaporizhzhia, Ukraine

[2] Oles Honchar Dnipro Natl Univ, 72 Gagarina Ave, UA-49000 Dnipro, Ukraine

[3] Natl Acad Sci Ukraine, State Sci Inst Inst Single Crystals, 60 Nauky Ave, UA-61000 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2017年 / 53卷 / 10期

关键词：

6-R-1-3-(2-aminophenyl)-1,2,4-triazin-5(2H)-ones; cyclic ketones; 1,2,4]triazino[2,3-c]quinazolines; anticonvulsant activity; (5+1) cyclocondensation; spectral characteristics; QUINAZOLINONE ALKALOIDS; INHIBITORS; CHEMISTRY;

D O I：

10.1007/s10593-017-2184-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Previously unknown 3'-R-1-spiro[(aza/oxa/thia)cycloalkyl-1(3, 4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones were obtained on the basis of (5+1) cyclocondensation reaction of substituted 6-R-1-3-(2-aminophenyl)-1,2,4-triazin-5(2De)-ones with cyclic ketones. It was established that the steric and electronic factors of cyclic ketones did not affect the reaction duration and product yields. The structure of the synthesized compounds was proved by (1)De and C-13 NMR spectroscopy, mass spectrometry, and X-ray structural analysis. The synthesized compounds were characterized as promising anticonvulsants.

引用

页码：1134 / 1147

页数：14

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