Cytokines of the IL-17 family in psoriasis

被引：10

作者：

Lauffer, Felix ^{[1
]}

Eyerich, Kilian ^{[1
]}

Boehncke, Wolf-Henning ^{[2
,3
]}

Asadullah, Khusru ^{[4
]}

Beissert, Stefan ^{[5
]}

Ghoreschi, Kamran ^{[6
]}

Schoen, Michael P. ^{[7
,8
]}

机构：

[1] Tech Univ Munich TUM, Dept Dermatol & Allergy Biederstein, Univ Hosp, Munich, Germany

[2] Univ Geneva, Univ Hosp Geneva, Div Dermatol & Venereol, Geneva, Switzerland

[3] Univ Geneva, Univ Hosp Geneva, Dept Pathol & Immunol, Geneva, Switzerland

[4] Dermatol Practice Potsdam, Potsdam, Germany

[5] Tech Univ Dresden, Carl Gustav Carus Univ Med Ctr, Dept Dermatol, Dresden, Germany

[6] Charite Univ Med Berlin, Dept Dermatol Venereol & Allergol, Berlin, Germany

[7] Gottingen Univ, Univ Med Ctr, Dept Dermatol Venereol & Allergol, Gottingen, Germany

[8] Lower Saxony Inst Occupat Dermatol, Gottingen, Germany

来源：

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT | 2020年

关键词：

S3; GUIDELINE; INFLAMMATION; NEUTROPHILS; CONTRIBUTES; VULGARIS; UPDATE;

D O I：

10.1111/ddg.14124

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.

引用

页码：675 / 681

页数：7

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