A convenient route to novel fluorinated 1,2,4,3-triazaphospholo[1,5-a]pyridines and pyrido[1,2-b][1,2,4,5]triazaphosphinines

被引：13

作者：

Assiri, Mohammed A. ^{[1
,2
]}

Abdel-Kariem, Somaia M. ^{[3
]}

Ali, Tarik E. ^{[3
]}

Yahia, I. S. ^{[4
,5
]}

机构：

[1] King Khalid Univ, Fac Sci, Chem Dept, Adv Mat & Green Chem, Abha, Saudi Arabia

[2] King Khalid Univ, RCAMS, Abha, Saudi Arabia

[3] Ain Shams Univ, Fac Educ, Dept Chem, Cairo, Egypt

[4] King Khalid Univ, Fac Sci, Dept Phys, AFMOL, Abha, Saudi Arabia

[5] Ain Shams Univ, Semicond Lab, Dept Phys, NLEBA,Fac Educ, Cairo, Egypt

来源：

ARKIVOC | 2018年

关键词：

1,6-Diaminopyridine; cyclization; 1,2,4,3-triazaphospholes; 1,2,4,5-triazaphosphinines; BIOLOGICAL EVALUATION; DERIVATIVES; ANTITUMOR; HYDRAZONES; DRUGS;

D O I：

10.24820/ark.5550190.p010.478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthetic approach to the construction of novel fluorinated 5-oxo(thioxo)-2-oxido(sulfido)-1,2,4,3-triazaphospholo[1,5-a]pyridines 2-14 and pyrido[1,2-b][1,2,4,5]triazaphosphinines 16, 19 and 22, was achieved. The method depends on the treatment of 1,6-diamino-4-(4-fluorophenyI)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (1) with some different types of phosphorus reagents such as phosphorus acid, and their esters, phosphorus halides as well as phosphorus sulfides. Structures of all the synthesized products were established by elemental analysis and spectral tools. [GRAPHICS] .

引用

页码：240 / 253

页数：14

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