A convenient route to novel fluorinated 1,2,4,3-triazaphospholo[1,5-a]pyridines and pyrido[1,2-b][1,2,4,5]triazaphosphinines

被引：13

作者：

Assiri, Mohammed A. ^{[1
,2
]}

Abdel-Kariem, Somaia M. ^{[3
]}

Ali, Tarik E. ^{[3
]}

Yahia, I. S. ^{[4
,5
]}

机构：

[1] King Khalid Univ, Fac Sci, Chem Dept, Adv Mat & Green Chem, Abha, Saudi Arabia

[2] King Khalid Univ, RCAMS, Abha, Saudi Arabia

[3] Ain Shams Univ, Fac Educ, Dept Chem, Cairo, Egypt

[4] King Khalid Univ, Fac Sci, Dept Phys, AFMOL, Abha, Saudi Arabia

[5] Ain Shams Univ, Semicond Lab, Dept Phys, NLEBA,Fac Educ, Cairo, Egypt

来源：

ARKIVOC | 2018年

关键词：

1,6-Diaminopyridine; cyclization; 1,2,4,3-triazaphospholes; 1,2,4,5-triazaphosphinines; BIOLOGICAL EVALUATION; DERIVATIVES; ANTITUMOR; HYDRAZONES; DRUGS;

D O I：

10.24820/ark.5550190.p010.478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthetic approach to the construction of novel fluorinated 5-oxo(thioxo)-2-oxido(sulfido)-1,2,4,3-triazaphospholo[1,5-a]pyridines 2-14 and pyrido[1,2-b][1,2,4,5]triazaphosphinines 16, 19 and 22, was achieved. The method depends on the treatment of 1,6-diamino-4-(4-fluorophenyI)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (1) with some different types of phosphorus reagents such as phosphorus acid, and their esters, phosphorus halides as well as phosphorus sulfides. Structures of all the synthesized products were established by elemental analysis and spectral tools. [GRAPHICS] .

引用

页码：240 / 253

页数：14

共 50 条

[1] 1,2,4,3-TRIAZAPHOSPHOLO[1,5-A]PYRIDINES
BANSAL, RK
GANDHI, N
SCHMIDPETER, A
KARAGHIOSOFF, K
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1994, 93 (1-4): : 381 - 382
[2] SYNTHESIS OF [1,2,4,3]TRIAZAPHOSPHOLO[1,5-A]PYRIDINES
BANSAL, RK
GANDHI, N
SCHMIDPETER, A
KARAGHIOSOFF, K
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1995, 50 (04): : 558 - 562
[3] 1,2-di-substituted 1,2-dihydro-1,2,4,3-triazaphospholo[4,5-a]quinolines
Buzykin, BI
Eliseenkova, RM
Zyablikova, TA
ZHURNAL OBSHCHEI KHIMII, 1996, 66 (03): : 526 - 526
[4] 1,2-Dihydro-1,2,4,3-triazaphospholo[4,5-a]quinolines as electron carriers in the electrochemical reduction of 1,1-dichloro-2-methoxycarbonyl-2-methylcyclopropane
Yanilkin, VV
Buzykin, BI
Eliseenkova, RM
Maksimyuk, NI
Nastapova, NV
RUSSIAN CHEMICAL BULLETIN, 1999, 48 (11) : 2065 - 2068
[5] 1,2-dihydro-1,2,4,3-triazaphospholo[4,5-a]quinolines as electron carriers in the electrochemical reduction of 1,1-dichloro-2-methoxycarbonyl-2-methylcyclopropane
V. V. Yanilkin
B. I. Buzykin
R. M. Eliseenkova
N. I. Maksimyuk
N. V. Nastapova
Russian Chemical Bulletin, 1999, 48 : 2065 - 2068
[6] Fused pyridines by a tandem aza-Wittig heterocyclization strategy:: Synthesis of 1,2,4-triazolo[1,5-a]pyridines and pyrido[1,2-b][1,2,4]triazines
Barsy, Magda A.
El Rady, Eman A.
El Latif, Fawi M. Abd
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 45 (03) : 773 - 778
[7] ABNORMAL FORMATION OF PYRAZOLO[1,5-A]PYRIDINES VIA THE DESULFURIZATION OF PYRIDO[1,2-B]-4,1,2-THIADIAZINE INTERMEDIATES
KAKEHI, A
ITO, S
ITO, M
HETEROCYCLES, 1984, 21 : 663 - 663
[8] NOVEL PYRIDO[1,2-B][1,2,4]TRIAZINES FROM 1,6-DIAMINO-PYRIDINES
ATANASOV, KD
LAFUENTE, P
QUINTEIRO, M
SEOANE, C
SOTO, JL
JOURNAL OF CHEMICAL RESEARCH-S, 1990, (06): : 186 - 187
[9] Chemistry of pyrido[1,2-b][1,2]oxazines, pyrido[1,2-b][1,2]thiazines, pyrido[1,2-b][1,2]pyridazines, and their benzologs: Part I
Hermecz, I
ADVANCES IN HETEROCYCLIC CHEMISTRY, VOL 69, 1998, 69 : 89 - 128
[10] Reactions with hydrazonoyl halides 60:: synthesis of thieno[2′,3′:4,51 pyrimidino[1,2-b][1,2,4,5]tetrazines, [1]benzothieno[2′,3′:4,5]pyrimidino [1,2-b][1,2,4,5]tetrazines, pyrazolo[3′,4′:4,5]pyrimidino[ 1,2-b] [1,2,4,5]tetrazines and pyrazolo[3,4-d]pyridazines
Abdelhamid, Abdou O.
Ismail, Zeineb H.
Abdel-Azim, Anhar
JOURNAL OF CHEMICAL RESEARCH, 2007, (10) : 609 - 616

← 1 2 3 4 5 →