Chiral gold(III) complexes: speciation, in vitro, and in vivo anticancer profile

被引：10

作者：

Arojojoye, Adedamola S. ^{[1
]}

Kim, Jong H. ^{[1
]}

Olelewe, Chibuzor ^{[1
]}

Parkin, Sean ^{[1
]}

Awuah, Samuel G. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA

[2] Univ Kentucky, Ctr Pharmaceut Res & Innovat, Coll Pharm, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Pharmaceut Sci, Coll Pharm, Lexington, KY 40536 USA

[4] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40536 USA

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 73期

关键词：

Mammals;

D O I：

10.1039/d2cc03081k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Emerging synthetic development of chiral gold(III) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C<^>N]Au(III)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

引用

页码：10237 / 10240

页数：4

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