Action of GABA-B antagonist on cortical epileptic afterdischarges in rats is similar to that of GABA-A antagonist

被引：3
|
作者：
Zivanovic, D
Bernásková, K
Kaminskij, Y
Mares, P [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic
[2] Sch Med, Inst Physiol, Belgrade, Serbia
[3] Charles Univ Prague, Fac Med 3, Dept Normal Pathol & Clin Physiol, Prague, Czech Republic
来源：
PHYSIOLOGICAL RESEARCH | 2003年 / 52卷 / 05期
关键词：
epileptic seizures; cerebral cortex; rat; CGP; 35348; bicuculline;
D O I：
10.33549/physiolres.930502
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Threshold intensities for epileptic phenomena induced by cortical stimulation were used for comparison of the action of GABA-B and GABA-A antagonists in rats with implanted electrodes. Both CGP 35348 (200 mg/kg i.p.) and bicuculline (4 mg/kg i.p.) significantly decreased thresholds for spike-and-wave afterdischarges and their motor counterpart (clonic seizures) whilst transition into the second, limbic type of afterdischarge as well as threshold for movements directly bound to stimulation remained uninfluenced by either drug.
引用
收藏
页码：651 / 655
页数：5
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