The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development

被引：0
|
作者：
Kerber, B
Monge, I
Mueller, M
Mitchell, PJ
Cohen, SM
机构：
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
[2] Univ Zurich, Inst Pharmacol, CH-8006 Zurich, Switzerland
来源：
DEVELOPMENT | 2001年 / 128卷 / 08期
关键词：
AP-2; limb development; joint formation; Notch; Drosophila;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.
引用
收藏
页码：1231 / 1238
页数：8
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