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Anti-tumor-promoting activity of diterpenes from Excoecaria agallocha

被引：0
|
作者：
Konishi, T
Takasaki, M
Tokuda, H
Kiyosawa, S
Konoshima, T [1 ]
机构：
[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan
[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1998年 / 21卷 / 09期
关键词：
diterpene; Excoecaria agallocha; Euphorbiaceae; anti-tumor-promoter; two-stage carcinogenesis;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To search for possible anti-tumor-promoters, we carried out the primary screening of seventeen diterpenes (1-17) isolated from the resinous wood of Excoecaria agallocha (Euphorbiaceae) using an in vitro synergistic assay system. Of these diterpenes, ent-16-hydroxy-3-oxo-13-epi-manoylolid (5), (13R,14R)-ent-8 alpha,13;14,15-diepoxy-13-epi-labda-3 beta-ol (8) ent-3 beta-hydroxy-15-beyeren-2-one (10) and ent-15-hydroxy-labda-8(17),13E-dien-3-one (14) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, IO exhibited remarkable anti-tumor-promoting activity in vivo on a two-stage carcinogenesis test of mouse tumor using 7,12-dimethylbenz[a]-anthracene (DMBA) as an initiator and TPA as a promoter.
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页码：993 / 996
页数：4
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