Cytotoxic C47-polyacetylene carboxylic acids from a marine Sponge pertrosia sp.

被引：18
|
作者：
Okamoto, Chikane
Nakao, Yoichi
Fujita, Tsuyoshi
Iwashita, Takashi
van Soest, W. M.
Fusetani, Nobuhiro
Matsunaga, Shigeki [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan
[2] Suntory Inst Bioorgan Res, Osaka 6180024, Japan
[3] Univ Amsterdam, Museum Zool, NL-1090 GT Amsterdam, Netherlands
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 11期
关键词：
D O I：
10.1021/np0702943
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents. Their structures were determined by interpretation of 2D NMR data and tandem FABMS data. Absolute stereochemistry of 3 was assigned by application of the modified Mosher analysis. Petroformynic acids exhibit moderate cytotoxic activity against P388 cells.
引用
收藏
页码：1816 / 1819
页数：4
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