Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates

被引：37

作者：

Butler, Michelle M. ^{[1
]}

Williams, John D. ^{[1
]}

Peet, Norton P. ^{[1
]}

Moir, Donald T. ^{[1
]}

Panchal, Rekha G. ^{[2
]}

Bavari, Sina ^{[2
]}

Shinabarger, Dean L. ^{[3
]}

Bowlin, Terry L. ^{[1
]}

机构：

[1] Microbiotix Inc, Worcester, MA 01605 USA

[2] USA, Med Res Inst Infect Dis, Frederick, MD USA

[3] Micromyx, Kalamazoo, MI USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期

关键词：

D O I：

10.1128/AAC.00484-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive bacteria, with MIC90 values of 0.004 to 0.5 mu g/ml. One bis-indole, MBX 1162, exhibited potent activity against all Gram-negative strains, with MIC90 values of 0.12 to 4 mu g/ml, even against high-level-resistant pathogens, and compared favorably to all comparator antibiotics. The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens.

引用

页码：3974 / 3977

页数：4

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