IN-VITRO ACTIVITY OF BIAPENEM AGAINST CLINICAL ISOLATES OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

被引：26
|
作者：
MALANOSKI, GJ
COLLINS, L
WENNERSTEN, C
MOELLERING, RC
ELIOPOULOS, GM
机构：
[1] NEW ENGLAND DEACONESS HOSP,DEPT MED,BOSTON,MA 02215
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期
关键词：
D O I：
10.1128/AAC.37.9.2009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activity of biapenem, a new carbapenem previously designated 1,627, was compared with those of imipenem and several other antimicrobial agents against 771 clinical bacterial isolates. Against gram-positive organisms, biapenem was found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. Against gram-negative organisms and Bacteroides fragilis, biapenem was at least as active as and often more active than imipenem, with MICs for 90% of the isolates two- to eightfold lower than those of imipenem.
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页码：2009 / 2016
页数：8
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