Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

被引：27

作者：

Ohmura, Shunya ^{[1
,2
,3
,4
]}

Marchetto, Aruna ^{[4
]}

Orth, Martin F. ^{[4
]}

Li, Jing ^{[1
,2
,3
]}

Jabar, Susanne ^{[5
,6
]}

Ranft, Andreas ^{[5
,6
]}

Vinca, Endrit ^{[1
,2
,3
]}

Ceranski, Katharina ^{[1
,2
,3
]}

Carreno-Gonzalez, Martha J. ^{[1
,2
,3
]}

Romero-Perez, Laura ^{[1
,2
,3
,4
]}

Wehweck, Fabienne S. ^{[4
]}

Musa, Julian ^{[1
,2
,3
,4
,7
]}

Bestvater, Felix ^{[8
]}

Knott, Maximilian M. L. ^{[4
]}

Hoelting, Tilman L. B. ^{[4
]}

Hartmann, Wolfgang ^{[9
]}

Dirksen, Uta ^{[5
,6
]}

Kirchner, Thomas ^{[10
,11
]}

Cidre-Aranaz, Florencia ^{[1
,2
,3
,4
]}

Grunewald, Thomas G. P. ^{[1
,2
,3
,4
,12
]}

机构：

[1] Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany

[2] German Canc Res Ctr, Div Translat Pediat Sarcoma Res B410, Neuenheimer Feld 280, D-69210 Heidelberg, Germany

[3] Hopp Childrens Canc Ctr KiTZ, Neuenheimer Feld 280, D-69210 Heidelberg, Germany

[4] Ludwig Maximilians Univ Munchen, Inst Pathol, Fac Med, Max Eder Res Grp Pediat Sarcoma Biol, Munich, Germany

[5] Univ Hosp Essen, West German Canc Ctr, Pediat 3, Essen, Germany

[6] German Canc Consortium DKTK, Partner Site Essen, Essen, Germany

[7] Heidelberg Univ Hosp, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany

[8] German Canc Consortium DKTK, Light Microscopy Facil, German Canc Res Ctr DKFZ, Heidelberg, Germany

[9] Univ Hosp Munster, Gerhard Domagk Inst Pathol, Div Translat Pathol, Munster, Germany

[10] Ludwig Maximilians Univ Munchen, Inst Pathol, Fac Med, Munich, Germany

[11] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany

[12] Heidelberg Univ Hosp, Inst Pathol, Heidelberg, Germany

来源：

MOLECULAR CANCER | 2021年 / 20卷 / 01期

关键词：

Ewing sarcoma; RRM2; Targeted therapy; Prognostic biomarker; Paediatric oncology; Triapine; Chemoresistance; RIBONUCLEOTIDE REDUCTASE INHIBITOR; GTI-2040 PLUS DOCETAXEL; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; PHASE-I/II; MANAGEMENT; RECURRENCE;

D O I：

10.1186/s12943-021-01393-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页数：7

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