Regulation of pancreatic β-cell function by the forkhead protein FoxO1

被引：93
|
作者：
Buteau, J.
Accili, D.
机构：
[1] Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA
[2] Hop Laval, Ctr Rech, Laval, PQ, Canada
[3] Univ Laval, Dept Anat & Physiol, Laval, PQ, Canada
来源：
DIABETES OBESITY & METABOLISM | 2007年 / 9卷
关键词：
beta-cell rest; diabetes; glycolysis; incretin; premature senescence; transcriptional repression;
D O I：
10.1111/j.1463-1326.2007.00782.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Forkhead transcription factors of the FoxO family play a critical role in cellular differentiation, proliferation, apoptosis and stress resistance. FoxO1 regulates glucose and lipid production in liver; food intake in the hypothalamus and cell differentiation in preadipocytes, myoblasts and vascular endothelium. In this review, we summarize recent literature on the role of FoxO1 in pancreatic beta cells. FoxO1 regulates beta-cell proliferation and protects against beta-cell failure induced by oxidative stress through NeuroD and MafA induction. In addition, FoxO1 nuclear exclusion is required for the proliferative effects of glucoincretin glucagon-like peptide-1 in islets. The data begin to outline an overarching role of FoxO1 in beta-cell function.
引用
收藏
页码：140 / 146
页数：7
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