Computational analysis of platelet adhesion and aggregation under stagnation point flow conditions

被引：6
|
作者：
Reininger, CB
Lasser, R
Rumitz, M
Böger, C
Schweiberer, L
机构：
[1] Univ Munich, Klinikum Innenstadt, Chirurg Klin & Poliklin, D-80366 Munich, Germany
[2] GSF, Natl Res Ctr Environm & Hlth, Inst Biomath & Biometry, Neuherberg, Germany
[3] Tech Univ Munich, Inst Anat, D-8000 Munich, Germany
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 1999年 / 29卷 / 01期
关键词：
stagnation point flow adhesio-aggregometry (SPAA); platelet adhesion; platelet aggregation; peripheral arterial disease (PAD); morphology; light intensity curve; mathematical model; K-pp; K-pw;
D O I：
10.1016/S0010-4825(98)00039-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The clinical relevance of platelet function assessment with stagnation point flow adhesio-aggregometry (SPAA) has been verified. Quantitative analysis of platelet adhesion and aggregation is possible by means of mathematical analysis of the dark-field, light intensity curves (growth curves) obtained during the SPAA experiment. We present a computational procedure for evaluating these curves, which was necessitated by, and is based on, actual clinical application. A qualitative growth curve classification, corresponding to a basic and distinct pattern of platelet deposition and characteristic of a regularly occurring clinical state is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1 / 18
页数：18
相关论文
共 50 条
  • [11] Hiemenz stagnation point flow with computational modelling of variety of boundary conditions
    Vishalakshi, A. B.
    Mahabaleshwar, U. S.
    Perez, L. M.
    Manca, O.
    [J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2023, 575
  • [12] Synergy of adhesive interactions in platelet adhesion and aggregation under flow
    Ruggeri, ZM
    Savage, B
    Dent, JA
    Saldivar, E
    [J]. THROMBOSIS AND HAEMOSTASIS, 1999, : 502 - 503
  • [13] PLATELET-ADHESION TO POLYMERS - TESTED IN A STAGNATION POINT FLOW CHAMBER WITHOUT ANTICOAGULATION
    WURZINGER, LJ
    SCHNEIDER, W
    JANSEN, B
    LANGEN, H
    SCHMIDSCHONBEIN, H
    [J]. HAEMOSTASIS, 1985, 15 (01) : 64 - 64
  • [14] COLLAGEN COATED GELATINE TUBES FOR INVESTIGATION OF PLATELET ADHESION AND SUBSEQUENT PLATELET-AGGREGATION UNDER CONTROLLED FLOW CONDITIONS
    MUGGLI, R
    BAUMGARTNER, HR
    [J]. THROMBOSIS ET DIATHESIS HAEMORRHAGICA, 1975, 34 (01): : 333 - 333
  • [15] Recombinant factor VIIa enhances platelet adhesion and aggregation under flow conditions at normal and reduced platelet count.
    Lisman, T
    Adelmeijer, J
    Cauwenberghs, S
    van Pampus, ECM
    Heemskerk, JWM
    de Groot, PG
    [J]. BLOOD, 2004, 104 (11) : 716A - 716A
  • [16] Models of platelet deposition in stagnation point flow
    David, T
    Thomas, S
    Walker, PG
    [J]. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING - 3, 2001, : 743 - 748
  • [17] Analysis of platelet adhesion to a collagen-coated surface under flow conditions: The involvement of glycoprotein VI in the platelet adhesion
    Moroi, M
    Jung, SM
    Shinmyozu, K
    Tomiyama, Y
    Ordinas, A
    DiazRicart, M
    [J]. BLOOD, 1996, 88 (06) : 2081 - 2092
  • [18] Development of a Method to Quantify Platelet Adhesion and Aggregation Under Static Conditions
    Baker-Groberg, Sandra M.
    Cianchetti, Flor A.
    Phillips, Kevin G.
    McCarty, Owen J. T.
    [J]. CELLULAR AND MOLECULAR BIOENGINEERING, 2014, 7 (02) : 285 - 290
  • [19] Development of a Method to Quantify Platelet Adhesion and Aggregation Under Static Conditions
    Sandra M. Baker-Groberg
    Flor A. Cianchetti
    Kevin G. Phillips
    Owen J. T. McCarty
    [J]. Cellular and Molecular Bioengineering, 2014, 7 : 285 - 290
  • [20] Platelet Adhesion to Polyurethane Urea Under Pulsatile Flow Conditions
    Navitsky, Michael A.
    Taylor, Joshua O.
    Smith, Alexander B.
    Slattery, Margaret J.
    Deutsch, Steven
    Siedlecki, Christopher A.
    Manning, Keefe B.
    [J]. ARTIFICIAL ORGANS, 2014, 38 (12) : 1046 - 1053
12345