Intrahippocampal administration of losartan improves learning and memory in rats with model of depression

被引：0
|
作者：
Ivanova, M. S. [1 ]
Tashev, R. E. [2 ,3 ]
机构：
[1] Med Univ Varna, Dept Physiol & Pathophysiol, M Drinov Str 55, Varna, Bulgaria
[2] Med Univ Sofia, Dept Pathophysiol, Zdrave Str 2, Sofia, Bulgaria
[3] Bulgarian Acad Sci, Dept Behav Neurobiol, Inst Neurobiol, Acad G Bonchev Str 23, Sofia, Bulgaria
来源：
BULGARIAN CHEMICAL COMMUNICATIONS | 2017年 / 49卷
关键词：
Losartan; Angiotensin II; Hippocampus; Depression; Learning; Memory; OLFACTORY BULBECTOMIZED RAT; OXIDATIVE STRESS; CAPTOPRIL TREATMENT; ALZHEIMERS-DISEASE; MAJOR DEPRESSION; RECEPTOR SUBTYPE; ANGIOTENSIN; AT(1); HIPPOCAMPUS; INHIBITION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The brain renin-angiotensin system is involved in learning and memory, but the role of angiotensin II and its receptors in these processes is not well established. The effects of losartan (angiotensin type 1 receptor antagonist) and angiotensin II, microinjected bilaterally into CA1 hippocampal area on learning and memory in rats with a model of depression (bilateral olfactory bulbectomy), using two avoidance paradigms: active avoidance (shuttle box) and passive avoidance (step through) were investigated. After stereotaxic implantation of guide cannulas into the CA1 area of dorsal hippocampus angiotensin II (0.5 mu g) and losartan (100 mu g) were microinjected separately, 5 minutes before each training session. It was found that intra-CA1 losartan reverses memory deficits induced by bulbectomy unlike angiotensin II which did not show any effect. The data suggest an involvement of angiotensin type 1 receptors in modulating memory processes in rats with model of depression.
引用
收藏
页码：169 / 174
页数：6
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