Novel and potent 6-chloro-3-pyridinylmethyl ligands for the α4β2 neuronal nicotinic acetylcholine receptor.

被引：0
|
作者：
Latli, B [1 ]
D'Amour, K [1 ]
Casida, JE [1 ]
机构：
[1] Univ Calif Berkeley, Dept ESPM, Environm Chem & Toxicol Lab, Berkeley, CA 94720 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 216卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
074-AGRO
引用
收藏
页码：U105 / U105
页数：1
相关论文
共 50 条
  • [31] A comparison of nicotinic ligand affinities for the neuronal nicotinic receptor subtypes α3β2, α3β4, α4β2, and α4β4 using novel liquid chromatography stationary phases
    Whittington, KC
    Moaddel, R
    Wainer, IW
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 22A - 22A
  • [32] Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding
    Hardick, DJ
    Blagbrough, IS
    Cooper, G
    Potter, BVL
    Critchley, T
    Wonnacott, S
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (24) : 4860 - 4866
  • [33] Structure-Activity Studies of Diazabicyclo[3.3.0]octane-Substituted Pyrazines and Pyridines as Potent α4β2 Nicotinic Acetylcholine Receptor Ligands
    Scanio, Marc J. C.
    Shi, Lei
    Bunnelle, William H.
    Anderson, David J.
    Helfrich, Rosalind J.
    Malysz, John
    Thorin-Hagene, Kirsten K.
    Van Handel, Ceclia E.
    Marsh, Kennan C.
    Lee, Chih-Hung
    Gopalakrishnant, Murali
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (21) : 7678 - 7692
  • [34] Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective α4β2 Nicotinic Acetylcholine Receptor Agonist
    Hansen, Camilla P.
    Jensen, Anders A.
    Christensen, Jeppe K.
    Balle, Thomas
    Lijefors, Tommy
    Frolund, Bente
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (23) : 7380 - 7395
  • [35] 5-azidoepibatidine:: An exceptionally potent photoaffinity ligand for neuronal α4β2 and α7 nicotinic acetylcholine receptors
    Zhang, NJ
    Tomizawa, M
    Casida, JE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (03) : 525 - 527
  • [36] Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-Conotoxin GIC
    Lee, Chewook
    Lee, Si-Hyung
    Kim, Do-Hyoung
    Han, Kyou-Hoon
    BMB REPORTS, 2012, 45 (05) : 275 - 280
  • [37] Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors
    Chi, SW
    Kim, DH
    Olivera, BM
    Mcintosh, JM
    Han, KH
    BIOCHEMICAL JOURNAL, 2004, 380 : 347 - 352
  • [38] Partial Agonists of the α3β4*Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats
    Chatterjee, Susmita
    Steensland, Pia
    Simms, Jeffrey A.
    Holgate, Joan
    Coe, Jotham W.
    Hurst, Raymond S.
    Shaffer, Christopher L.
    Lowe, John
    Rollema, Hans
    Bartlett, Selena E.
    NEUROPSYCHOPHARMACOLOGY, 2011, 36 (03) : 603 - 615
  • [39] Site-directed mutagenesis of α3β4 neuronal nicotinic acetylcholine receptor agonist binding sites
    Naseem, AA
    Brown, JT
    Comet, MA
    Marsland, H
    Prince, RJ
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134
  • [40] Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression
    Nirogi, Ramakrishna
    Mohammed, Abdul Rasheed
    Shinde, Anil K.
    Ravella, Srinivasa Rao
    Bogaraju, Narsimha
    Subramanian, Ramkumar
    Mekala, Venkat Reddy
    Palacharla, Raghava Choudary
    Muddana, Nageswararao
    Thentu, Jagadeesh Babu
    Bhyrapuneni, Gopinadh
    Abraham, Renny
    Jasti, Venkat
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (06) : 2833 - 2853
12345