Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid

被引：11
|
作者：
Dankwardt, SM
Phan, TM
Krstenansky, JL
机构：
[1] Syntex Discovery Research, Chemical Research and Development, Palo Alto, 94304, CA
来源：
MOLECULAR DIVERSITY | 1996年 / 1卷 / 02期
关键词：
solid-phase synthesis; combinatorial approach; non-peptide library; 3-amino-5-hydroxybenzoic acid;
D O I：
10.1007/BF01721326
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A non-peptide library of 2001 compounds has been prepared utilizing solid-phase techniques. The split/combine method was demonstrated to work well to form mixtures of compounds based on 3-amino-5-hydroxybenzoic acid as a core structure. The benzoic acid of the core structure served as the attachment point for the resin and the amino and hydroxy positions were variably substituted.
引用
收藏
页码：113 / 120
页数：8
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