The Expression of MGMT and ErbB2 in Human Glioma

被引：0
|
作者：
Sun Chun-ming [1 ]
Wang Zhi-min [1 ]
Zheng Shi-ying [2 ]
Xu Qi-nian [1 ]
Zhang Shi-ming [1 ]
Zhou Dai [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215006, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Cardio Thorac Surg, Suzhou 215006, Peoples R China
来源：
2009 INTERNATIONAL CONFERENCE ON FUTURE BIOMEDICAL INFORMATION ENGINEERING (FBIE 2009) | 2009年
关键词：
Glioma: Drug-resistance gene: RT-PCR; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; BREAST-CANCER; METHYLTRANSFERASE; CHEMOTHERAPY; CELLS; O-6-BENZYLGUANINE; RESISTANCE;
D O I：
10.1109/FBIE.2009.5405896
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2(p<0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.
引用
收藏
页码：253 / +
页数：2
相关论文
共 50 条
  • [21] The ErbB2 receptor modulates EGFR-mediated signals and regulates migration of human glioma cells
    Rappl, A.
    Schlegel, J.
    ACTA NEUROPATHOLOGICA, 2006, 112 (03) : 374 - 374
  • [22] Androgens regulation of the ERBB1 and ERBB2 oncogene expression in human prostate cancer cells.
    Pignon, Jean-Christophe
    Delacroix, Laurence
    Waltregny, David
    Winkler, Rosita
    ACTA CLINICA BELGICA, 2006, 61 (02): : 95 - 95
  • [23] Neuregulin receptors erbB2 and erbB4 in failing human myocardium - Depressed expression and attenuated activation
    Rohrbach, S
    Niemann, B
    Silber, RE
    Holtz, J
    BASIC RESEARCH IN CARDIOLOGY, 2005, 100 (03) : 240 - 249
  • [24] Nuclear ErbB2 expression in hepatocytes in liver disease
    Paula Döring
    Diego F. Calvisi
    Frank Dombrowski
    Virchows Archiv, 2021, 478 : 309 - 318
  • [25] Nuclear ErbB2 expression in hepatocytes in liver disease
    Doering, Paula
    Calvisi, Diego F.
    Dombrowski, Frank
    VIRCHOWS ARCHIV, 2021, 478 (02) : 309 - 318
  • [26] Quantitative measures of oestrogen receptor and ERBB2 expression
    Hayes, Daniel F.
    LANCET ONCOLOGY, 2007, 8 (03): : 184 - 185
  • [27] Amplification and expression of EGFR and ERBB2 in Wilms tumor
    Vasei, Mohammad
    Modjtahedi, Helmout
    Ale-booyeh, Oreineb
    Mosallaei, Ahmad
    Kajbafzadeh, Abdol Mohammad
    Shahriari, Mehdi
    Ghaderi, Abbas Ali
    Soleymanpour, Hossein
    Kosari, Farid
    Moch, Holger
    Sauter, Guido
    CANCER GENETICS AND CYTOGENETICS, 2009, 194 (02) : 88 - 95
  • [28] Expression of ERBB2 and BCL-2 in synovial sarcoma
    Krsková, Lenka
    Hilská, Irena
    Augustiñaková, Alena
    Kalinová, Markéta
    Mrhalová, Marcela
    Neradová, Marie
    Kodet, Roman
    MODERN PATHOLOGY, 2006, 19 : 181 - 181
  • [29] Expression of ErBb family members and levels of phosphorylated ErBb2 in breast tumours
    Cicenas, J.
    Vuaroqueaux, V.
    Labuhn, M.
    Kueng, W.
    Wight, E.
    Urban, P.
    Neumann, R.
    Eppenberger, U.
    Eppenberger-Castori, S.
    EJC SUPPLEMENTS, 2004, 2 (03): : 179 - 179
  • [30] A new human antitumor immunoreagent specific for ErbB2
    De Lorenzo, C
    Palmer, DB
    Piccoli, R
    Ritter, MA
    D'Alessio, G
    CLINICAL CANCER RESEARCH, 2002, 8 (06) : 1710 - 1719
12345