Linking Long Noncoding RNA Localization and Function

被引：821
|
作者：
Chen, Ling-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol,Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Key Lab, Shanghai, Peoples R China
[2] Shanghai Tech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai, Peoples R China
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 09期
关键词：
MESSENGER-RNAS; CHROMATIN INTERACTIONS; NUCLEAR PARASPECKLES; CANCER METASTASIS; BINDING PROTEINS; GENE-EXPRESSION; CIRCULAR RNAS; BREAST-CANCER; TRIPLE-HELIX; XIST RNA;
D O I：
10.1016/j.tibs.2016.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have revealed the regulatory potential of many long noncoding RNAs (IncRNAs). Most IncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of IncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of IncRNAs has the potential to provide new insights into their biogenesis and specialized functions.
引用
收藏
页码：761 / 772
页数：12
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