Synthesis and structure of functionalized podands containing 4,7-dihydrotetrazolo[1,5-a]pyrimidine ring. Differently substituted dihydropyrimidine podands

被引：4
|
作者：
Filatova, Elena S. [1 ,2 ]
Fedorova, Olga V. [1 ]
Slepukhin, Pavel A. [1 ,2 ]
Rusinov, Gennady L. [1 ,2 ]
Charushin, Valery N. [1 ,2 ]
机构：
[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, 22 S Kovalevskoi,20 Akad Skaya St, Ekaterinburg 620990, Russia
[2] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
dihydropyrimidine thione podands; 4,7-dihydrotetrazolo[1,5-a]pyrimidine podands; differently substituted podands; transport polyether spacer; Biginelli reaction;
D O I：
10.1007/s10593-018-2373-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 3-oxobutanoate-containing polyethers with benzaldehyde and 5-aminotetrazole in the presence of polyphosphoric acid was used to synthesize podands containing two terminal tetrazolo[1,5-a] dihydropyrimidine groups. Byproducts were isolated and identified as podands containing different substituents - one 4,7-dihydrotetrazolo[1,5-a] pyrimidine ring system and a free hydroxy group at the other terminus of the polyether chain. Analogous differently substituted podands, including one 3,4-dihydropyrimidine-2(1H)-thione moiety, were isolated from the reactions of 3-oxobutanoate-containing polyethers with benzaldehyde and thiourea.
引用
收藏
页码：971 / 976
页数：6
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