The RecQ DNA Helicases in DNA Repair

被引：222
|
作者：
Bernstein, Kara A. [1 ]
Gangloff, Serge [2 ,3 ]
Rothstein, Rodney [1 ]
机构：
[1] Columbia Univ, Med Ctr, Dept Genet & Dev, New York, NY 10032 USA
[2] CEA, DSV, iRCM, SIGRR,LERA, F-92265 Fontenay Aux Roses, France
[3] CNRS, UMR 217, F-92265 Fontenay Aux Roses, France
来源：
ANNUAL REVIEW OF GENETICS, VOL 44 | 2010年 / 44卷
关键词：
RecQ; Werner syndrome; Bloom syndrome; Rothmund-Thomson syndrome; homologous recombination; DNA repair; BLOOMS-SYNDROME HELICASE; SYNDROME GENE-PRODUCT; TOPOISOMERASE-III-ALPHA; ROTHMUND-THOMSON-SYNDROME; REPLICATION PROTEIN-A; ESCHERICHIA-COLI RECQ; FAITHFUL CHROMOSOME SEGREGATION; HOLLIDAY JUNCTION DISSOLVASOME; WERNERS-SYNDROME PROTEIN; MEIOTIC CROSSING-OVER;
D O I：
10.1146/annurev-genet-102209-163602
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double :Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well IS at specific genomic loci such as telomeres.
引用
收藏
页码：393 / 417
页数：25
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