Aquaporins in the kidney: physiology and pathophysiology

被引：93
|
作者：
Su, Wen [1 ]
Cao, Rong [2 ,3 ]
Zhang, Xiao-yan [4 ]
Guan, Youfei [4 ]
机构：
[1] Shenzhen Univ, Hlth Sci Ctr, Dept Pathophysiol, Shenzhen, Peoples R China
[2] Shenzhen Univ, Dept Nephrol, Affiliated Hosp 1, Shenzhen, Peoples R China
[3] Second Peoples Hosp Shenzhen, Shenzhen, Peoples R China
[4] Dalian Med Univ, Sch Basic Med Sci, Adv Inst Med Sci, Dept Physiol & Pathophysiol, Dalian, Peoples R China
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2020年 / 318卷 / 01期
关键词：
aquaporin; nephrogenic diabetes insipidus; nuclear receptors; urine concentration; water homeostasis; RENAL COLLECTING DUCT; NEPHROGENIC DIABETES-INSIPIDUS; WATER CHANNEL EXPRESSION; MICE LACKING AQUAPORIN-1; FARNESOID X RECEPTOR; ISCHEMIA-REPERFUSION; MEMBRANE EXPRESSION; AQP2; EXPRESSION; DOWN-REGULATION; ANGIOTENSIN-II;
D O I：
10.1152/ajprenal.00304.2019
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The kidney is the central organ involved in maintaining water and sodium balance. In human kidneys, nine aquaporins (AQPs), including AQP1-8 and AQP11. have been found and are differentially expressed along the renal tubules and collecting ducts with distinct and critical roles in the regulation of body water homeostasis and urine concentration. Dysfunction and dysregulation of these AQPs result in various water balance disorders. This review summarizes current understanding of physiological and pathophysiological roles of AQPs in the kidney, with a focus on recent progress on AQP2 regulation by the nuclear receptor transcriptional factors. This review also provides an overview of AQPs as clinical biomarkers and therapeutic targets for renal diseases.
引用
收藏
页码：F193 / F203
页数：11
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