The role of nitric oxide in the biological activity of prolactin in the mouse mammary gland

被引:11
|
作者
Bolander, FF [1 ]
机构
[1] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA
关键词
prolactin; receptor up-regulation; alpha-lactalbumin; nitric oxide; mammary gland;
D O I
10.1016/S0303-7207(00)00448-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In mouse mammary epithelial cells, prolactin transiently elevates nitric oxide (NO) to a maximum of 6 nmol/mg protein at 15 min, after which levels fall rapidly. This stimulation can be achieved by as little as 100 ng prolactin/ml and can be mimicked by 100 mug sodium nitroprusside/ml. NO is both necessary and sufficient to mediate the prolactin-induced redistribution of its receptor from internal pools to the cell surface. NO can also enhance DNA synthesis stimulated by submaximal prolactin concentrations (50 ng/ml), but it is not necessary at pharmacological prolactin concentrations (1 mug/ml). In contrast, NO completely inhibits alpha -lactalbumin production. In summary, prolactin transiently elevates NO to enhance DNA synthesis and suppress premature differentiation; thereafter, NO declines, DNA synthesis ceases and differentiation proceeds. This data suggest that NO may mediate some of the effects of prolactin on growth in the mammary gland. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:91 / 98
页数:8
相关论文
共 50 条
  • [31] Role of the superoxide anion on biological activity of nitric oxide produced by the endothelium
    Arnal, JF
    Rami, J
    Souchard, JP
    Tack, I
    Besombes, JP
    ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 1996, 104 (04) : D27 - D28
  • [32] BIOLOGICAL ACTIVITY OF PHOSPHATE ESTERS IN MAMMARY GLAND EXTRACTS
    CRAINE, EM
    HANSEN, RG
    JOURNAL OF DAIRY SCIENCE, 1954, 37 (09) : 1027 - 1034
  • [33] Prolactin Regulation of Mammary Gland Development
    Samantha R. Oakes
    Renee L. Rogers
    Matthew J. Naylor
    Christopher J. Ormandy
    Journal of Mammary Gland Biology and Neoplasia, 2008, 13 : 13 - 28
  • [34] Prolactin regulation of mammary gland development
    Oakes, Samantha R.
    Rogers, Renee L.
    Naylor, Matthew J.
    Ormandy, Christopher J.
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2008, 13 (01) : 13 - 28
  • [35] Mammary gland development and the prolactin receptor
    Binart, N
    Ormandy, CJ
    Kelly, PA
    BIOLOGY OF THE MAMMARY GLAND, 2000, 480 : 85 - 92
  • [36] INCREASES IN ENZYME ACTIVITY OF MOUSE MAMMARY EXPLANTS INDUCED BY PROLACTIN
    JONES, EA
    FORSYTH, IA
    JOURNAL OF ENDOCRINOLOGY, 1969, 43 (01) : R41 - &
  • [37] Alpha hemolysin effect on phagocytic activity and production of nitric oxide from bovine mammary gland macrophages
    Velázquez-Ordoñez, V
    Iglesias-Sahagún, JG
    Saltijeral-Oaxaca, J
    Gorodezky-Laufferman, C
    Tizard, I
    REVUE DE MEDECINE VETERINAIRE, 2000, 151 (07) : 783 - 783
  • [38] Prolactin signaling in mammary gland development
    Hennighausen, L
    Robinson, GW
    Wagner, KU
    Liu, XW
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 7567 - 7569
  • [39] Effect of prolactin on mammary gland secretion
    Stewart, HL
    Pratt, JP
    ENDOCRINOLOGY, 1939, 25 (03) : 347 - 353
  • [40] Distribution of prolactin receptors suggests an intraductal role for prolactin in the mouse and human mammary gland, a finding supported by analysis of signaling in polarized monolayer cultures
    Eric K. Ueda
    KuangTzu Huang
    Virginia Nguyen
    Marco Ferreira
    Saudade Andre
    Ameae M. Walker
    Cell and Tissue Research, 2011, 346 : 175 - 189