Real-time monitoring and control of microbial bioprocesses with focus on the specific growth rate: current state and perspectives

被引:55
|
作者
Schuler, Moira Monika [1 ]
Marison, Ian William [1 ]
机构
[1] Dublin City Univ, Lab Integrated Bioproc, Dublin 9, Ireland
基金
爱尔兰科学基金会;
关键词
Growth model; Monod model; Recombinant protein production; Process analytical technology (PAT); FED-BATCH CULTIVATION; RECOMBINANT PROTEIN-PRODUCTION; PROCESS ANALYTICAL TECHNOLOGY; VIABLE BIOMASS MEASUREMENTS; ARTIFICIAL NEURAL-NETWORK; ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; CELL-DENSITY; ONLINE ESTIMATION; PICHIA-PASTORIS;
D O I
10.1007/s00253-012-4095-z
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Understanding the growth characteristics of microorganisms is an essential step in bioprocessing, not only because product formation may be growth-associated but also because they might influence cell physiology and thereby product quality. The specific growth rate, a key variable of many bioprocesses, cannot be measured directly and relies on the estimation through other measurable variables such as biomass, substrate, or product concentrations. Techniques for real-time estimation of the specific growth rate in microbial fed-batch cultures are discussed in the present paper. The advantages and limitations of different models and various monitoring techniques are discussed, highlighting the importance of the specific growth rate in the development of fast, reliable, and robust processes for the production of high-value products such as recombinant proteins.
引用
收藏
页码:1469 / 1482
页数:14
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