Metal free direct formation of various substituted pyrido[2′,1′: 2,3]imidazo[4,5-c]isoquinolin-5-amines and their further functionalization

被引：14

作者：

Tber, Z. ^{[1
,2
]}

Hiebel, M. -A. ^{[1
]}

Allouchi, H. ^{[3
]}

El Hakmaoui, A. ^{[2
]}

Akssira, M. ^{[2
]}

Guillaumet, G. ^{[1
]}

Berteina-Raboin, S. ^{[1
]}

机构：

[1] Univ Orleans, Inst Chim Organ & Analyt, UMR CNRS 7311, F-45067 Orleans, France

[2] URAC 22 Univ Hassan II Mohammedia Casablanca, Equipe Chim Bioorgan & Analyt, Mohammadia 28800, Morocco

[3] Univ Tours, Lab Phys, Equipe RICM UMR ISP 1282, Tours, France

来源：

RSC ADVANCES | 2015年 / 5卷 / 44期

关键词：

ONE-POT; PYRAZINES; SEQUENCE; DIVERSE; ACCESS;

D O I：

10.1039/c5ra03703d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Original substituted pyrido[2',1':2,3] imidazo[4,5-c] isoquinolin-5-amines have been prepared following a Groebke-Blackburn-Bienayme MCR combined with an N-deprotection and a spontaneous final cyclization step in moderate to good yields. The flexibility of the described method enables the introduction of diverse groups in the 6 and 7 positions on the resulting scaffold using commercially available starting materials. Furthermore, a Buchwald-Hartwig cross coupling with a wide range of aryl and hetaryl halides has been successfully reported using our heterocyclic primary amine derivatives.

引用

页码：35201 / 35210

页数：10

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