Preoperative Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio Predict Survival Outcomes of Patients With Hepatocellular Carcinoma After Curative Resection

被引:12
|
作者
Qu, Zhen [1 ]
Lu, Yun-jie [1 ]
Feng, Jia-Wei [1 ]
Chen, Yu-xiang [1 ]
Shi, Long-qing [1 ]
Chen, Jing [1 ]
Rambaran, Navin [2 ]
Duan, Yun-Fei [1 ]
He, Xiao-zhou [1 ]
机构
[1] Soochow Univ, Affiliated Hosp 3, Changzhou Peoples Hosp 1, Changzhou, Peoples R China
[2] Georgetown Hosp Complex, Dept Gen Surg, Georgetown, Guyana
来源
FRONTIERS IN ONCOLOGY | 2022年 / 11卷
基金
中国国家自然科学基金;
关键词
hepatocellular carcinoma; prognostic nutrition index; neutrophil-to-lymphocyte ratio; survival; prognostic factors; INFLAMMATION; MARKERS;
D O I
10.3389/fonc.2021.823054
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Increasing evidence indicates that preoperative prognostic indices can serve as independent predictors of survival in patients with cancer. However, the applicability of these indices in patients with hepatocellular carcinoma (HCC) is controversial. This study aims to investigate the prognostic value of these indices in patients with HCC after curative hepatectomy. We retrospectively analyzed the data of 215 patients who underwent curative resection for HCC. Prognostic indices including prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) were evaluated by comparing by the area under the curve (AUC). Univariate analysis and multivariate analysis were performed to identify independent prognostic factors. Additionally, risk factors were combined to predict the survival of patients. We found that serum albumin concentration, tumor diameter, tumor stage, degree of differentiation, PNI, and NLR were independent prognostic factors for overall survival (OS). Vascular invasion, tumor stage, degree of differentiation, and PNI were independent prognostic factors for recurrence-free survival (RFS). The cutoff value of the PNI and NLR was 43.75 and 3.29, respectively. Patients with low NLR and high PNI had the best outcomes, potentially indicative of the intensive antitumor effects of the immune system. Moreover, patients with at least three risk factors had a significantly lower OS and RFS compared with those with two or fewer risk factors. This new nomogram based on PNI and NLR may provide an accessible and individualized prediction of survival and recurrence for HCC patients.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio Are Not Prognostic Biomarkers in Rectal Cancer Patients with Curative Resection
    Portale, Giuseppe
    Cavallin, Francesco
    Valdegamberi, Alessandro
    Frigo, Flavio
    Fiscon, Valentino
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2018, 22 (09) : 1611 - 1618
  • [22] Preoperative prognostic nutritional index predicts survival of patients with intrahepatic cholangiocarcinoma after curative resection
    Akguel, Ozguer
    Bagante, Fabio
    Olsen, Griffin
    Cloyd, Jordan M.
    Weiss, Matthew
    Merath, Katiuscha
    Alexandrescu, Sorin
    Marques, Hugo P.
    Aldrighetti, Luca
    Maithel, Shishir K.
    Pulitano, Carlo
    Bauer, Todd W.
    Shen, Feng
    Poultsides, George A.
    Soubrane, Olivier
    Martel, Guillaume
    Koerkamp, B. Groot
    Guglielmi, Alfredo
    Itaru, Endo
    Pawlik, Timothy M.
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2018, 118 (03) : 422 - 430
  • [23] Preoperative neutrophil-to-lymphocyte ratio behaves as an independent prognostic factor even in patients with postoperative complications after curative resection for gastric cancer
    Jaume Tur-Martínez
    Javier Osorio
    Noelia Pérez-Romero
    Noelia Puértolas-Rico
    Manuel Pera
    Salvadora Delgado
    Joaquín Rodríguez-Santiago
    [J]. Langenbeck's Archives of Surgery, 2022, 407 : 1017 - 1026
  • [24] Preoperative Prognostic Nutritional Index Predicts Survival of Patients With Intrahepatic Cholangiocarcinoma After Curative Resection
    Akgul, O.
    Bagante, F.
    Weiss, M.
    Merath, K.
    Alexandrescu, S.
    Marques, H. P.
    Aldrighetti, L.
    Maithel, S. K.
    Pulitano, C.
    Bauer, T. W.
    Shen, F.
    Poultsides, G.
    Soubrane, O.
    Martel, G.
    Koerkamp, B. G.
    Guglielmi, A.
    Itaru, E.
    Pawlik, T. M.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2018, 25 : S135 - S136
  • [25] Preoperative neutrophil-to-lymphocyte ratio behaves as an independent prognostic factor even in patients with postoperative complications after curative resection for gastric cancer
    Tur-Martinez, Jaume
    Osorio, Javier
    Perez-Romero, Noelia
    Puertolas-Rico, Noelia
    Pera, Manuel
    Delgado, Salvadora
    Rodriguez-Santiago, Joaquin
    [J]. LANGENBECKS ARCHIVES OF SURGERY, 2022, 407 (03) : 1017 - 1026
  • [26] Neutrophil-lymphocyte Ratio Plus Prognostic Nutritional Index Predicts the Outcomes of Patients with Unresectable Hepatocellular Carcinoma After Transarterial Chemoembolization
    Liu, Chang
    Li, Lei
    Lu, Wu-sheng
    Du, Hua
    Yan, Lu-nan
    Yang, Jia-yin
    Wen, Tian-fu
    Zeng, Guo-jun
    Jiang, Li
    Yang, Jian
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [27] Neutrophil-lymphocyte Ratio Plus Prognostic Nutritional Index Predicts the Outcomes of Patients with Unresectable Hepatocellular Carcinoma After Transarterial Chemoembolization
    Chang Liu
    Lei Li
    Wu-sheng Lu
    Hua Du
    Lu-nan Yan
    Jia-yin Yang
    Tian-fu Wen
    Guo-jun Zeng
    Li Jiang
    Jian Yang
    [J]. Scientific Reports, 7
  • [29] Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer
    Shimizu, Katsuhiko
    Okita, Riki
    Saisho, Shinsuke
    Maeda, Ai
    Nojima, Yuji
    Nakata, Masao
    [J]. WORLD JOURNAL OF SURGICAL ONCOLOGY, 2015, 13
  • [30] Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer
    Katsuhiko Shimizu
    Riki Okita
    Shinsuke Saisho
    Ai Maeda
    Yuji Nojima
    Masao Nakata
    [J]. World Journal of Surgical Oncology, 13