Chemical constituents and their bioactivities from the fruits of Vitex negundo var. cannabifolia

被引：9

作者：

Fang, Sheng-Tao ^{[1
]}

Kong, Na-Na ^{[1
,3
]}

Yan, Bing-Fei ^{[1
,2
]}

Yang, Cui-Yun ^{[1
]}

Wang, Jian-Hua ^{[1
]}

Liu, Su-Jing ^{[1
]}

Jin, Hai -Zhu ^{[2
]}

Xia, Chuan-Hai ^{[1
]}

机构：

[1] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resources Utilizat, Yantai, Peoples R China

[2] Yantai Univ, Chem & Chem Engn Coll, Yantai, Peoples R China

[3] Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Vitex negundo var. cannabifolia; chemical constituent; cytotoxicity; brine shrimp lethality; SEEDS; LIGNANS;

D O I：

10.1080/14786419.2016.1174228

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the fruits of Vitex negundo var. cannabifolia led to the isolation of 22 compounds (1-22). Their structures were elucidated mainly by spectroscopic analysis and comparison with the literature data. Among them, compounds 1 and 2 were two new artificial lignans. Primary bioassay showed that the polymethoxyflavones 9-12 displayed moderate-to-weak cytotoxicity against human HepG2 and rat C6 cell lines, while the triterpenoids 13-17 exhibited significant brine shrimp lethality with LC50 values of 7.5-29.4 mu M.

引用

页码：2856 / 2860

页数：5

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