Academic Centers for Excellence on Youth Violence Prevention (ACE), which support a broad range of activities over and above RO1-type research projects, can add significantly to a community's capacity to respond to youth violence. We use the example of the Harvard Youth Violence Prevention Center to describe the types of research-practice collaborations these centers can promote, as well as the ways in which these collaborations can foster adoption of program planning, development, implementation and evaluation practices consistent with evidence-based approaches to youth violence prevention. Throughout, we describe the ways in which the existence of a center led, under the ACE format, to research, policy and practice opportunities that would not have existed in the absence of a center.