High-intensity interval training in people with mild multiple sclerosis: a mixed-methods feasibility study

Background/Aims High-intensity interval training has received increased attention as a mode of exercise, including as a therapy in clinical populations. This study investigated the acceptability of a high-intensity interval training intervention in people with mild multiple sclerosis. Methods Participants attended two sessions a week for the 6-week intervention. Each session consisted of 6-10 sets of 60-second high-intensity intervals interspersed with 120 seconds of recovery. The acceptability, intervention adherence and safety of the high-intensity interval training protocol and estimates of treatment effects (fitness, physical activity levels, fatigue and quality of life) were used to determine intervention feasibility. Qualitative interviews were used to explore the acceptability of the intervention. Results A total of 11 people with mild multiple sclerosis consented to participate in a 6-week high-intensity interval intervention. One participant dropped out of the intervention. The participants expressed apprehension before the intervention but attendance at the exercise sessions was high (87%). Participants experienced some symptom exacerbation following sessions, although none were serious. Improvements were seen in fitness, physical activity, fatigue and health-related quality of life. Conclusions The study findings suggest that high-intensity interval training is acceptable, safe and may offer disease-related benefits for the participants. Participants did experience some symptom exacerbation and further studies are needed to determine the long-term appeal of high-intensity interval training for people with mild multiple sclerosis.