Long-term antibody persistence induced by a combined hepatitis A and B vaccine in children and adolescents

被引：15
|
作者：
Diaz-Mitoma, Francisco [2 ]
Law, Barbara [3 ]
Subramanya, Archana [4 ]
Hoet, Bernard [1 ]
机构：
[1] GlaxoSmithKline Biol, B-1330 Rixensart, Belgium
[2] Childrens Hosp Eastern Ontario, Ottawa, ON K1H 8L1, Canada
[3] Univ Manitoba, Winnipeg, MB, Canada
[4] GlaxoSmithKline Biol, Bangalore, Karnataka, India
来源：
VACCINE | 2008年 / 26卷 / 14期
关键词：
combined hepatitis A and B vaccine; immunogenicity; long-term protection;
D O I：
10.1016/j.vaccine.2008.01.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two cohorts, comprising of subjects aged 1-6 years and 6-15 years were vaccinated with Twinrix (TM) according to a 0-, 1- and 6-month schedule. The 1-6 years cohort was followed up for 7.5 years and the 6-15 years cohort for 10 years. At the latest follow-up time point, all subjects were seropositive for anti-HAV antibodies, while 86.5% (32/37) and 95.5% (21/22) had anti-HBs >= 10mlU/ml. in the 1-6 years and in the 6-15 years cohort. The geometric mean concentrations (GMCs; mIU/ml) were 233 and 680 for anti-HAV antibodies, and 147 and 165 for anti-HBs antibodies, in the 1-6 years and 6-15 years cohorts, respectively. The high persistence of circulating anti-HAV and anti-HBs antibodies in children and adolescents demonstrates the long-term protection offered by Twinrix (TM) in these age groups. (c) 2008 Published by Elsevier Ltd.
引用
收藏
页码：1759 / 1763
页数：5
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