Oxidative N-heterocyclic carbene-catalyzed [3+3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones

被引：9

作者：

Wang, Zhan-Yong ^{[1
]}

Yang, Ting ^{[2
]}

Wang, Kai-Kai ^{[1
]}

Chen, Rongxiang ^{[1
]}

Liu, Menghan ^{[1
]}

Liu, Hongxin ^{[3
,4
]}

机构：

[1] Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China

[2] Xinxiang Univ, Med Coll, Xinxiang 453003, Henan, Peoples R China

[3] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou, Peoples R China

[4] Wenzhou Univ, Inst New Mat & Ind Technol, Wenzhou, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; AURONES; UMPOLUNG;

D O I：

10.1039/d0qo00161a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile route to benzofuran-fused delta-lactones was developed via an N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction, giving the expected products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). It should be noted that benzofuran-fused pyrones can be obtained stepwise in one pot with excellent yields (up to 96%) by using this methodology.

引用

页码：1011 / 1015

页数：5

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