Oxidative N-heterocyclic carbene-catalyzed [3+3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones

被引：9
|
作者：
Wang, Zhan-Yong [1 ]
Yang, Ting [2 ]
Wang, Kai-Kai [1 ]
Chen, Rongxiang [1 ]
Liu, Menghan [1 ]
Liu, Hongxin [3 ,4 ]
机构：
[1] Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China
[2] Xinxiang Univ, Med Coll, Xinxiang 453003, Henan, Peoples R China
[3] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou, Peoples R China
[4] Wenzhou Univ, Inst New Mat & Ind Technol, Wenzhou, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 08期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; AURONES; UMPOLUNG;
D O I：
10.1039/d0qo00161a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile route to benzofuran-fused delta-lactones was developed via an N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction, giving the expected products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). It should be noted that benzofuran-fused pyrones can be obtained stepwise in one pot with excellent yields (up to 96%) by using this methodology.
引用
收藏
页码：1011 / 1015
页数：5
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