Gout: Current Insights and Future Perspectives

被引:38
|
作者
Smith, Howard S. [1 ]
Bracken, Donna [2 ]
Smiths, Joshua M. [3 ]
机构
[1] Albany Med Coll, Dept Anesthesiol, Albany, NY 12208 USA
[2] Cornell Univ Med Coll, New York, NY USA
[3] Albany Coll Pharm, Pharmaceut Res Inst, Delmar, NY USA
来源
JOURNAL OF PAIN | 2011年 / 12卷 / 11期
关键词
Gout; treatment; allopurinol; febuxostat; pegloticase; IL-1; inhibitors; pain; PYROPHOSPHATE DEPOSITION DISEASE; XANTHINE-OXIDASE INHIBITOR; TREATMENT-FAILURE GOUT; DOUBLE-BLIND; CONTROLLED-TRIAL; REFRACTORY GOUT; INFLAMMASOME ACTIVATION; SONOGRAPHIC ASSESSMENT; ORAL PREDNISOLONE; HEALTHY-SUBJECTS;
D O I
10.1016/j.jpain.2011.06.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Gout is a relatively common inflammatory arthritis that is typically known to occur in middle-aged men. The prevalence of gout appears to be shifting, however, and is increasing in the elderly population. Gout is characterized by severely intense pain and can greatly impact patient quality of life. The study of gout and associated conditions appears to have received research attention in the past, however there is a resurgence in gout interest due to the abundance of novel evidence surrounding its diagnosis, pathophysiology, and treatment. In this review we describe a general overview of gout including its assessment/diagnosis, clinical presentations, predisposing factors, pathophysiology, abortive and prophylactic therapy to control gouty inflammation, and the potential future direction of gout treatment. Perspective: Gout is an underappreciated and extremely painful condition. Over the last 2 years new thought on pathophysiology of gout taking into account the inflammasome and new therapeutic agents have changed management strategies. (C) 2011 by the American Pain Society
引用
收藏
页码:1113 / 1129
页数:17
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