Gout is a relatively common inflammatory arthritis that is typically known to occur in middle-aged men. The prevalence of gout appears to be shifting, however, and is increasing in the elderly population. Gout is characterized by severely intense pain and can greatly impact patient quality of life. The study of gout and associated conditions appears to have received research attention in the past, however there is a resurgence in gout interest due to the abundance of novel evidence surrounding its diagnosis, pathophysiology, and treatment. In this review we describe a general overview of gout including its assessment/diagnosis, clinical presentations, predisposing factors, pathophysiology, abortive and prophylactic therapy to control gouty inflammation, and the potential future direction of gout treatment. Perspective: Gout is an underappreciated and extremely painful condition. Over the last 2 years new thought on pathophysiology of gout taking into account the inflammasome and new therapeutic agents have changed management strategies. (C) 2011 by the American Pain Society
机构:
Department of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, ItalyDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Tinelli, Andrea
Malvasi, Antonio
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Department of Obstetrics and Gynecology, Santa Maria Hospital, Bari, ItalyDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Malvasi, Antonio
Gustapane, Sarah
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机构:
Department of Obstetrics and Gynaecology, SS. Annunziata Hospital, Chieti, ItalyDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Gustapane, Sarah
Buscarini, Maurizio
论文数: 0引用数: 0
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机构:
Director of Department of Urology, Campus Biomedico University, Roma, ItalyDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Buscarini, Maurizio
Gill, Indy S.
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机构:
The University of Southern California (USC), United StatesDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Gill, Indy S.
Stark, Michael
论文数: 0引用数: 0
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机构:
The New European Surgical Academy (NESA), Berlin, Germany
The USP Hospital, Mallorca, SpainDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Stark, Michael
Nezhat, Farr R.
论文数: 0引用数: 0
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机构:
Division of Gynecologic Oncology and Minimally Invasive Surgery, Department of Obstetrics and Gynecology, St. Luke's Roosevelt Medical Center, New York, United States
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, NY 10019, United StatesDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
Nezhat, Farr R.
Mettler, Liselotte
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机构:
Kiel School of Gynaecological Endoscopy, Department of Obstetrics and Gynaecology, University Hospitals Schleswig Holstein, Campus Kiel, GermanyDepartment of Obstetrics and Gynecology, Division of Experimental Endoscopic Surgery, Imaging, Minimally Invasive Therapy and Technology, Vito Fazzi Hospital, Lecce, Italy
机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Harahap, Urip
Syahputra, Rony Abdi
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机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Syahputra, Rony Abdi
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Ahmed, Amer
Nasution, Azhari
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Nasution, Azhari
Wisely, Wenny
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Wisely, Wenny
Sirait, Maureen Lazurit
论文数: 0引用数: 0
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机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Sirait, Maureen Lazurit
Dalimunthe, Aminah
论文数: 0引用数: 0
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机构:
Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Dalimunthe, Aminah
Zainalabidin, Satirah
论文数: 0引用数: 0
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机构:
Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Toxicol & Hlth Risk Study, Kuala Lumpur, MalaysiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Zainalabidin, Satirah
Taslim, Nurpudji Astuti
论文数: 0引用数: 0
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机构:
Hasanuddin Univ, Fac Med, Dept Nutr, Div Clin Nutr, Makassar, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Taslim, Nurpudji Astuti
Nurkolis, Fahrul
论文数: 0引用数: 0
h-index: 0
机构:
State Islamic Univ Sunan Kalijaga UIN Sunan Kalija, Dept Biol Sci, Yogyakarta, IndonesiaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
Nurkolis, Fahrul
Kim, Bonglee
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Coll Korean Med, Dept Pathol, Seoul, South Korea
Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul, South KoreaUniv Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia
机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Wei, Xin
Pan, Yanan
论文数: 0引用数: 0
h-index: 0
机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Pan, Yanan
Zhang, Ziqi
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South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Zhang, Ziqi
Cui, Jingyi
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机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Cui, Jingyi
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Yin, Renli
Li, Huashou
论文数: 0引用数: 0
h-index: 0
机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Li, Huashou
Qin, Junhao
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h-index: 0
机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Qin, Junhao
Li, Adela Jing
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h-index: 0
机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
Li, Adela Jing
Qiu, Rongliang
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机构:
South China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R ChinaSouth China Agr Univ, Coll Nat Resources & Environm, Guangzhou 510642, Peoples R China
机构:
Rush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Sapienza Univ, St Andrea Hosp, Dept Urol, I-00189 Rome, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Franco, Antonio
Manfredi, Celeste
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机构:
Rush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Luigi Vanvitelli Univ, Dept Woman Child & Gen & Specialized Surg, Urol Unit, I-81100 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Manfredi, Celeste
Fasanella, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Fasanella, Daniela
Abate, Marco
论文数: 0引用数: 0
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机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Abate, Marco
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La Rocca, Roberto
Crocerossa, Fabio
论文数: 0引用数: 0
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机构:
Magna Graecia Univ Catanzaro, Dept Urol, I-88100 Catanzaro, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Crocerossa, Fabio
Iossa, Vincenzo
论文数: 0引用数: 0
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机构:
Antonio Cardarelli Hosp, Dept Androl, I-80131 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Iossa, Vincenzo
Falagario, Ugo Giovanni
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机构:
Univ Foggia, Dept Urol & Organ Transplantat, I-71122 Foggia, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Falagario, Ugo Giovanni
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Cirillo, Luigi
Altieri, Vincenzo Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy
Humanitas Gavazzeni, Dept Urol, I-24125 Bergamo, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Altieri, Vincenzo Maria
Di Mauro, Ernesto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Di Mauro, Ernesto
Crocetto, Felice
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Crocetto, Felice
Barone, Biagio
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机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Barone, Biagio
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Cilio, Simone
Pandolfo, Savio Domenico
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Pandolfo, Savio Domenico
Aveta, Achille
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机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Aveta, Achille
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Mirone, Vincenzo
Franzese, Corrado Aniello
论文数: 0引用数: 0
h-index: 0
机构:
ASL Napoli 3 Sud, I-80121 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Franzese, Corrado Aniello
Arcaniolo, Davide
论文数: 0引用数: 0
h-index: 0
机构:
Luigi Vanvitelli Univ, Dept Woman Child & Gen & Specialized Surg, Urol Unit, I-81100 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Arcaniolo, Davide
Napolitano, Luigi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Urol Unit, I-80138 Naples, ItalyRush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA
Napolitano, Luigi
Lee, Joo Yong
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机构:Rush Univ, Med Ctr, Dept Urol, Chicago, IL 60612 USA