Agents for the Treatment of Gout: Current Advances and Future Perspectives

被引：15

作者：

Zeng, Xiaoyi ^{[1
]}

Liu, Yajing ^{[1
]}

Fan, Yuxin ^{[1
]}

Wu, Di ^{[1
]}

Meng, Yangyang ^{[1
]}

Qin, Mingze ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 66卷 / 21期

关键词：

SEQUENCE-BASED DESIGN; XANTHINE-OXIDASE INHIBITORS; URIC-ACID; BIOLOGICAL EVALUATION; URATE TRANSPORTER; HYPERURICEMIC PATIENTS; POLYGONATUM-ODORATUM; SMALL MOLECULES; DOUBLE-BLIND; PHASE; 2A;

D O I：

10.1021/acs.jmedchem.3c01710

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gout is characterized by hyperuricemia and the deposition of monosodium urate (MSU) crystals around joints. Despite the availability of several drugs on the market, its treatment remains challenging owing to the notable side effects, such as hepatorenal toxicity and cardiovascular complications, that are associated with most existing agents. This perspective aims to summarize the current research progress in the development of antigout agents, particularly focusing on xanthine oxidase (XO) and urate anion transporter 1 (URAT1) inhibitors from a medicinal chemistry viewpoint and their preliminary structure-activity relationships (SARs). This perspective provides valuable insights and theoretical guidance to medicinal chemists for the discovery of antigout agents with novel chemical structures, better efficiency, and lower toxicity.

引用

页码：14474 / 14493

页数：20

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