A modernized water maze for investigation of the spatial memory in rats

被引：0
|
作者：
Lunin, SM [1 ]
Nesterov, VV [1 ]
Nesterova, IV [1 ]
Bobkova, NV [1 ]
机构：
[1] Russian Acad Sci, Inst Cell Biophys, Pushchino, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2001年 / 51卷 / 06期
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D O I：
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中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A method for evaluation of impairments of spatial memory in rats is put forward. Sensitivity of the advanced method based on the principles of Morris' water maze was compared with that of the classic prototype. Efficiency of the advanced method was assessed by dose- and time-dependent effects of agroclavine on the spatial memory of rats. Agroclavine (10 mu g/kg) was shown to produce spatial memory impairment in rats. The obtained results also indicate that the modernized maze is more sensitive in revealing impairments of the. spatial memory in rats than the classic water maze.
引用
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页码：762 / 766
页数：5
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