Activation of functional arylzincs prepared from aryl iodides and highly enantioselective addition to aldehydes

被引：41

作者：

DeBerardinis, Albert M. ^{[1
]}

Turlington, Mark ^{[1
]}

Pu, Lin ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 13期

关键词：

D O I：

10.1021/ol8008478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easily available chiral ligand (S)-1 is found to activate the nucleophilic reaction of the arylzincs prepared in situ from the reaction of aryl iodides with Et2Zn. Both high yields and high enantioselectivity (up to >99% ee) for the reaction of these arylzincs with a variety of aldehydes are obtained. The mild reaction conditions and the good functional group tolerance make this catalytic asymmetric process synthetically useful.

引用

页码：2709 / 2712

页数：4

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