An effective enantioselective approach to the securinega alkaloids:: Total synthesis of (-)-norsecurinine

被引：44
|
作者：
Alibés, R [1 ]
Bayón, P [1 ]
de March, P [1 ]
Figueredo, M [1 ]
Font, J [1 ]
García-García, E [1 ]
González-Gálvez, D [1 ]
机构：
[1] Univ Autonoma Barcelona, Dept Quim, Bellaterra 08193, Spain
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 22期
关键词：
D O I：
10.1021/ol0522079
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield.
引用
收藏
页码：5107 / 5109
页数：3
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