Role of Imaging in Neoadjuvant Therapy for Breast Cancer

被引:93
|
作者
Dialani, Vandana
Chadashvili, Tamuna
Slanetz, Priscilla J.
机构
[1] Beth Israel Deaconess Med Ctr, Dept Radiol, Div Breast Imaging, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
POSITRON-EMISSION-TOMOGRAPHY; PATHOLOGICAL COMPLETE RESPONSE; TUMOR SIZE; CLINICAL EXAMINATION; SYSTEMIC THERAPY; RESIDUAL DISEASE; EARLY PREDICTION; PREOPERATIVE CHEMOTHERAPY; PHYSICAL-EXAMINATION; COMPUTED-TOMOGRAPHY;
D O I
10.1245/s10434-015-4403-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Neoadjuvant chemotherapy (NAC) involves administration of chemotherapeutic agents to patients with newly diagnosed breast cancer prior to definitive surgical treatment. Assessment of disease response to chemotherapeutic agents in vivo prior to any surgical intervention is necessary as medical oncologists are commonly tailoring or changing therapy during NAC based on response. It can also maximize the pathologic complete response (pCR) rate, resulting in more women undergoing breast conservation rather than mastectomy. Although some studies show a pCR to NAC in only 13-26 % of women, recent studies have shown higher pCR rates, especially for HER2-positive disease treated with targeted anti-HER2 therapy. Thus, accurate imaging tools for quantifying disease response are critical in the evaluation and management of patients undergoing NAC. There is currently no standard imaging method for monitoring response to therapy. Response to therapy tends to vary by tumor subtype and can be accurately assessed on imaging. We review the role of imaging before and after neoadjuvant therapy and discuss the advantages and limitations of currently available modalities, including mammography, ultrasonography, magnetic resonance imaging, and nuclear imaging.
引用
收藏
页码:1416 / 1424
页数:9
相关论文
共 50 条
  • [41] Role of Magnetic Resonance Imaging in the Evaluation of Breast Cancer Response to Neoadjuvant Chemotherapy
    Pasquero, Giorgia
    Surace, Alessandra
    Ponti, Antonio
    Bortolini, Massimiliano
    Tota, Donatella
    Mano, Maria Piera
    Arisio, Riccardo
    Benedetto, Chiara
    Bau, Maria Grazia
    [J]. IN VIVO, 2020, 34 (02): : 909 - 915
  • [42] Potential role of photoacoustic imaging in neoadjuvant chemotherapy response monitoring in breast cancer
    Casey, M. C.
    Ennis, R.
    Walsh, S.
    Brown, J. A. L.
    Dwyer, R. M.
    Leahy, M. J.
    Kerin, M. J.
    [J]. BRITISH JOURNAL OF SURGERY, 2015, 102 : 26 - 26
  • [43] Breast conservation following neoadjuvant therapy for breast cancer
    Catanuto, Giuseppe
    Rocco, Nicola
    Nava, Maurizio B.
    [J]. MINERVA CHIRURGICA, 2018, 73 (03) : 297 - 299
  • [44] Role of radiation therapy on the use of primary ("neoadjuvant") systemic treatment of breast cancer
    Souchon, Rainer
    Dunst, J. rgen
    Hartmann, Karl Axel
    [J]. STRAHLENTHERAPIE UND ONKOLOGIE, 2006, 182 (04) : 202 - 209
  • [45] The Role of Postmastectomy Radiation Therapy in Patients With Breast Cancer Responding to Neoadjuvant Chemotherapy
    Bazan, Jose G.
    White, Julia R.
    [J]. SEMINARS IN RADIATION ONCOLOGY, 2016, 26 (01) : 51 - 58
  • [46] Emerging role of taxanes in adjuvant and neoadjuvant therapy for breast cancer - The potential and the questions
    Goble, S
    Bear, HD
    [J]. SURGICAL CLINICS OF NORTH AMERICA, 2003, 83 (04) : 943 - +
  • [47] Clarifying the Role of Neoadjuvant Therapy in Breast Cancer The Connolly/Stearns Article Reviewed
    Zelnak, Amelia
    [J]. ONCOLOGY-NEW YORK, 2010, 24 (02): : 149 - 149
  • [48] Apoptosis associated genes and their role in predicting responses to neoadjuvant breast cancer therapy
    Tvrdik, D.
    Skalova, H.
    Dundr, P.
    Stanek, L.
    Povysil, C.
    Petruzelka, L.
    [J]. VIRCHOWS ARCHIV, 2012, 461 : S171 - S172
  • [49] MR imaging for rectal cancer: the role in staging the primary and response to neoadjuvant therapy
    Battersby, Nick J.
    Moran, Brendan
    Yu, Stanley
    Tekkis, Paris
    Brown, Gina
    [J]. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2014, 8 (06) : 703 - 719
  • [50] Role of MR Imaging in Neoadjuvant Therapy Monitoring
    Le-Petross, Huong T.
    Lim, Bora
    [J]. MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA, 2018, 26 (02) : 207 - +