Genetic architecture of body size in mammals

被引：66
|
作者：
Kemper, Kathryn E. [1 ]
Visscher, Peter M. [2 ,3 ]
Goddard, Michael E. [1 ,4 ]
机构：
[1] Univ Melbourne, Fac Land & Environm, Parkville, Vic 3010, Australia
[2] Univ Queensland, Diamantina Inst, Princess Alexandra Hosp, Brisbane, Qld 4102, Australia
[3] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
[4] AgriBiosci Ctr, Victorian Dept Primary Ind, Bundoora, Vic 3083, Australia
来源：
GENOME BIOLOGY | 2012年 / 13卷 / 04期
基金：
澳大利亚研究理事会;
关键词：
Human height; mutation effects; mutation-selection balance; GENOME-WIDE ASSOCIATION; DE-LANGE-SYNDROME; DOMINANT-NEGATIVE MUTATION; GROWTH-FACTOR RECEPTOR-3; BIOLOGICAL PATHWAYS; MISSENSE MUTATION; HORMONE RECEPTOR; MARFAN-SYNDROME; COMPLEX TRAITS; COMMON;
D O I：
10.1186/gb-2012-13-4-244
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.
引用
收藏
页数：13
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