Increased Expression of Immune Checkpoint Regulators LAG3 and CD70 in the Tumor Cells and Microenvironment in Immunodeficiency Associated Lymphoproliferative Disorders

被引：0

作者：

Sanchez, Sandra ^{[1
]}

Cabrera, Luis Veloza ^{[2
,3
]}

Masaoutis, Christos ^{[4
]}

Buehler, Marco ^{[1
]}

Ribera, Inmaculada ^{[5
]}

Sellares, Anna ^{[1
]}

Arnaldos Perez, Cristina ^{[1
]}

Castillo Giron, Carlos ^{[1
]}

Frigola, Gerard ^{[5
]}

Guerrero Pineda, Jose ^{[6
]}

Lopez del Campo, Ricardo ^{[1
]}

Juan, Manel ^{[6
]}

Jares, Pedro ^{[5
]}

Lekakis, Lazaros ^{[7
]}

Ramos, Juan ^{[7
]}

Balsas, Patricia ^{[1
]}

Amador, Virginia ^{[1
]}

Antoni Bombi, Josep ^{[8
]}

Mira, Aurea ^{[1
]}

Balague, Olga ^{[6
]}

Martinez, Antonio ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin IDIBAPS, Barcelona, Spain

[2] CHU Vaudois, Lausanne, Switzerland

[3] Univ Lausanne, Lausanne, Switzerland

[4] Natl & Kapodistrian Univ Athens, Athens, Greece

[5] Hosp Clin Barcelona, Barcelona, Spain

[6] Univ Barcelona, Hosp Clin, Barcelona, Spain

[7] Univ Miami, Miller Sch Med, Sylvester Canc Ctr, Miami, FL 33136 USA

[8] Hosp Clin Barcelona, Barcelona, Spain

来源：

MODERN PATHOLOGY | 2022年 / 35卷 / SUPPL 2期

关键词：

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

942

引用

页码：1016 / 1017

页数：2

共 39 条

[31] IMMUNE CELL PROFILING IN BONE MARROW OF MYELOMA PATIENTS POST AUTOLOGUS STEM CELL TRANSPLANT SHOWS PRESENCE OF CYTOTOXIC CD4 AND CD8 CELLS, WITH PROMINENT LAG-3 EXPRESSION AND OTHER CHECKPOINT MARKERS
Alrasheed, N.
Furness, A.
De-Silva, D.
Galas-Filipowicz, D.
Chin, M.
Lee, L.
Henry, J.
Pule, M.
Quezada, S. A.
Yong, K.
HAEMATOLOGICA, 2017, 102 : 496 - 496
[32] Tumor microenvironment associated with increased pretreatment density of activated PD-1+LAG-3+/- TIM-3-CD8+T cells facilitates clinical response to axicabtagene ciloleucel (axi-cel) in patients (pts) with large B-cell lymphoma.
Galon, Jerome
Scholler, Nathalie
Perbost, Regis
Turcan, Sarah
Danan, Corinne
Locke, Frederick Lundry
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Miklos, David Bernard
Jacobson, Caron A.
Lekakis, Lazaros J.
Lin, Yi
Ghobadi, Armin
Chou, Justin
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Xue, Allen
Rossi, John M.
Bot, Adrian
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
[33] YAP/STAT3 inhibited CD8+ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages
Wang, Chen
Shen, Ningning
Guo, Qingling
Tan, Xiaohua
He, Shaozhong
CANCER MEDICINE, 2023, 12 (15): : 16295 - 16309
[34] Functional and phenotypic changes in natural killer cells expressing immune checkpoint receptors PD-1, CTLA-4, LAG-3, and TIGIT in non-small cell lung cancer: the comparative analysis of tumor microenvironment, peripheral venous blood, and tumor-draining veins
Esen, Fehim
Cikman, Duygu Ilke
Engin, Ayse
Turna, Akif
Batur, Sebnem
Oz, Buge
Turna, Hande Zeynep
Deniz, Gunnur
Aktas Cetin, Esin
IMMUNOLOGIC RESEARCH, 2025, 73 (01)
[35] Silencing MICAL2 Expression in Pancreatic Cancer Cells rewires the tumor microenvironment through the IL1-a/p38 MAP kinase/STAT-3 axis and Sensitizes Tumors to Immune Checkpoint Blockade therapy
Garg, Bharti
Mose, Evangeline
Esparaza, Edgar
Patel, Jay
Medari, Rithika
Martsinkovskiy, Alexei
Bishop, Carrie
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Engler, Adam
Katira, Parag
Tiriac, Herve
Lowy, Andrew M.
CANCER RESEARCH, 2024, 84 (17)
[36] Increased intraepithelial CD3+T-lymphocytes and high PD-L1 expression on tumor cells are associated with a favorable prognosis in esophageal squamous cell carcinoma and allow prognostic immunogenic subgrouping
Jesinghaus, Moritz
Steiger, Katja
Slotta-Huspenina, Julia
Drecoll, Enken
Pfarr, Nicole
Meyer, Petra
Konukiewitz, Bjoern
Bettstetter, Marcus
Wieczorek, Kathrin
Ott, Katja
Feith, Markus
Langer, Rupert
Weichert, Wilko
Specht, Katja
Boxberg, Melanie
ONCOTARGET, 2017, 8 (29) : 46756 - 46768
[37] Elraglusib (9-ING-41), a selective small-molecule inhibitor of glycogen synthase kinase-3 beta, reduces expression of immune checkpoint molecules PD-1, TIGIT and LAG-3 and enhances CD8+ T cell cytolytic killing of melanoma cells
Shaw, Gary
Cavalcante, Ludimila
Giles, Francis J.
Taylor, Alison
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)
[38] Elraglusib (9-ING-41), a selective small-molecule inhibitor of glycogen synthase kinase-3 beta, reduces expression of immune checkpoint molecules PD-1, TIGIT and LAG-3 and enhances CD8+ T cell cytolytic killing of melanoma cells
Gary Shaw
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Francis J. Giles
Alison Taylor
Journal of Hematology & Oncology, 15
[39] The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1β-converting enzyme-deficient or Bcl2-expressing transgenic mice
Priceputu, E
Rodrigue, I
Chrobak, P
Poudrier, J
Mak, TW
Hanna, Z
Hu, CY
Kay, DG
Jolicoeur, P
JOURNAL OF VIROLOGY, 2005, 79 (10) : 6377 - 6391

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