The impact of axillary ultrasound with biopsy in overtreatment of early breast cancer

被引:12
|
作者
del Riego, Javier [1 ]
Diaz-Ruiz, Maria Jesus [2 ]
Teixido, Milagros [3 ]
Ribe, Judit [4 ]
Vilagran, Mariona [1 ]
Canales, Lydia [5 ]
Sentis, Melcior [6 ]
机构
[1] Univ Autonoma Barcelona, Parc Tauli Hosp Univ, UDIAT Ctr Diagnost, Inst Invest Innovacio Parc Tauli I3PT,Dept Radiol, Barcelona, Spain
[2] Althaia Xarxa Assistencial Univ Manresa, Dept Radiol, Breast Imaging, 1-3 Dr Joan Soler St, Barcelona, Spain
[3] Consorci Sanitari Terrassa, Dept Radiol, Breast Imaging, S-N Torrebonica Av, Barcelona, Spain
[4] Hosp Gen Vic, Consorci Hosp Vic, Dept Radiol, Breast Imaging, 1 Francesc Pla El Vigata St, Barcelona, Spain
[5] Univ Hosp, Fdn Privada Hosp Asil Granollers, Hosp Gen Granollers, Dept Radiol,Breast Imaging, S-N Francesc Ribas Av, Barcelona, Spain
[6] Hosp Univ Mutua Terrassa, Dept Radiol, Breast Imaging, Barcelona, Spain
关键词
Axillary ultrasonography; Fine-needle axillary biopsy; Sentinel lymph node biopsy; Overtreatment; Axillary surgery; LYMPH-NODE DISSECTION; NEEDLE-BIOPSY; Z0011; TRIAL; TUMOR BURDEN; METAANALYSIS; MANAGEMENT; UTILITY; ERA;
D O I
10.1016/j.ejrad.2017.11.018
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: (a) To compare the axillary tumor burden detected by fine-needle aspiration cytology (FNAC) versus sentinel lymph node biopsy (SLNB). (b) To evaluate the relationship between axillary tumor burden and the number of suspicious lymph nodes detected by axillary ultrasonography (US). (c) To calculate the false-positive and false-negative rates for FNAC in patients fulfilling ACOSOG Z0011 criteria. Methods: Retrospective multicenter cross-sectional study of 355 pT1 breast cancers. SLNB and axillary lymph node dissection (ALND) were gold standards. Low axillary burden (<= 2 positive lymph nodes); high burden (> 2 positive lymph nodes). Patients ACOSOG Z0011: false-positive (positive FNAC + low burden), false-negative (negative FNAC + high burden). Results: High axillary burden: in entire series 38.5% FNAC+ vs. 5.7% SLNB+ (p < 0.0001). In subgroup fulfilling ACOSOG Z0011 criteria: 45.5% vs 6.7%, respectively (p < 0.001). 61 positive axillary US. With 1 suspicious node on axillary US: 95.6% had <= 2 involved nodes (including pN0); with 2 suspicious nodes: 60% had > 2 involved nodes. In ACOSOG Z0011 patients, with 1 suspicious node, 93.7% had <= 2 involved nodes. Of the 37 FNAC in ACOSOG Z0011patients: 54.5% false-positives for high burden; 3.8% false-negatives. Conclusions: FNAC-positive tumors have greater axillary burden, even in patients fulfilling ACOSOG Z0011 criteria. Using axillary US/FNAC to triage patients meeting Z0011 criteria may result in axillary overtreatment. The number of suspicious nodes seen in axillary US is related with the final axillary burden and should be taken into account when deciding to do FNAC in patients fulfilling ACOSOG Z0011 criteria.
引用
收藏
页码:158 / 164
页数:7
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