Susceptibilities of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum to a new quinolone, trovafloxacin (CP-99,219)

The susceptibilities of mycoplasmas to a new quinolone, trovafloxacin (CP-99,219), were compared,vith those to sparfloxacin and ofloxacin, Mycoplasma pneumoniae was as susceptible to trovafloxacin (MIC = 0.25 mu g/ml) as to sparfloxacin and fourfold less susceptible to ofloxacin. Mycoplasma hominis was highly susceptible to trovafloxacin (MIC = 0.06 mu g/ml) and sparfloxacin (MIC = 0.03 mu g/ml) and less susceptible to ofloxacin (MIC = 0.5 mu g/ml). Ureaplasma urealyticum was most susceptible to trovafloxacin, with susceptibilities ranging from 0.06 to 0.5 mu g/ml compared with 0.25 to 1.0 mu g of sparfloxacin per ml and 1 to 4 mu g of ofloxacin per ml .