Synthesis and glycosidase inhibitory activity of enantiopure polyhydroxylated octahydroindoles and decahydroquinolines, analogs to castanospermine

被引：22

作者：

Gravier-Pelletier, C ^{[1
]}

Maton, W ^{[1
]}

Bertho, G ^{[1
]}

Le Merrer, Y ^{[1
]}

机构：

[1] Univ Paris 05, Chim & Biochim Pharmacol & Toxicol Lab, CNRS, UMR 8601, F-75270 Paris 06, France

来源：

TETRAHEDRON | 2003年 / 59卷 / 44期

关键词：

alkaloid; azasaccharide; bicyclic compounds; castanospermine; glycosidase; octahydroindole; decahydroquinoline; reductive amination;

D O I：

10.1016/j.tet.2003.09.044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of new enantiopure polyhydroxylated octahydroindoles and decahydroquinolines, analogs to castanospermine, via a double reductive amination of enantiopure cyclic ketoaldehyde, and their inhibitory activity against alpha- or beta-D-glucosidases, alpha-D-mannosidase and alpha-L-fucosidase are described. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8721 / 8730

页数：10

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