Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies

被引：4
|
作者：
Chandra, Vishnu M. [1 ]
Wilkins, Luke R. [1 ]
Brautigan, David L. [2 ]
机构：
[1] Univ Virginia Hlth Syst, Dept Radiol & Med Imaging, 1215 Lee St,POB 800170, Charlottesville, VA 22908 USA
[2] Univ Virginia Hlth Syst, Dept Microbiol Immunol & Canc Biol, 1215 Lee St,POB 800170, Charlottesville, VA 22908 USA
来源：
RADIOLOGY-IMAGING CANCER | 2022年 / 4卷 / 04期
关键词：
Animal Studies; Interventional-Vascular; Molecular Imaging-Clinical; Translation; Molecular Imaging-Cancer; Chemoembolization; Liver; VX2; TUMOR-MODEL; RAT MODEL; TRANSARTERIAL EMBOLIZATION; RADIOFREQUENCY ABLATION; LIVER-CANCER; CHEMOEMBOLIZATION; WOODCHUCK; HEPATOMA; EXPRESSION; MICRORNAS;
D O I：
10.1148/rycan.210098
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Animal models play a crucial role in developing and testing new therapies for hepatocellular carcinoma (HCC), providing preclinical evidence prior to exploring human safety and efficacy outcomes. The interventional radiologist must weigh the advantages and disadvantages of various animal models available when testing a new local-regional therapy. This review highlights the currently available animal models for testing local-regional therapies for HCC and details the importance of considering animal genetics, tumor biology, and molecular mechanisms when ultimately choosing an animal model. (C)RSNA, 2022
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页数：9
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