Effect of erythropoietin administration on the expression of brain-derived neurotrophic factor, stromal cell-derived Factor-1, and neuron-specific enolase in traumatic brain injury: A literature review

被引:6
|
作者
Said, Muhammad Fadli [1 ]
Islam, Andi Asadul [1 ]
Massi, Muhammad Nasrum [2 ]
Prihantono [3 ]
机构
[1] Hasanuddin Univ, Dept Neurosurg, Fac Med, Makassar, South Sulawesi, Indonesia
[2] Hasanuddin Univ, Dept Microbiol, Fac Med, Makassar, South Sulawesi, Indonesia
[3] Hasanuddin Univ, Dept Surg, Fac Med, Makassar, South Sulawesi, Indonesia
来源
关键词
Traumatic brain injury; Erythropoietin; SDF-1; Neuroprotection; BDNF; NSE; RECOMBINANT-HUMAN-ERYTHROPOIETIN; IMPROVES FUNCTIONAL RECOVERY; DOUBLE-BLIND; RECEPTORS; APOPTOSIS; P75(NTR); MODEL; RATS; TRKB;
D O I
10.1016/j.amsu.2021.102666
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Traumatic brain injury (TBI) is a major cause of death and lifelong disability around the world that predominantly affects young and middle-aged people. Erythropoietin (EPO) is a promising therapeutic agent for a variety of neurological injuries including TBI due to its neuroprotective effects. Here we review the impact of exogenous erythropoietin administration on the expression of brain-derived neurotrophic factor (BDNF), stromal cell derived factor-1 (SDF-1), and neuron-specific enolase (NSE) levels in cerebrospinal fluid after TBI as biomarkers for neuron regeneration and survival to predict TBI outcome.
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页数:4
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